NP_001028458.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,934 Da
NCBI Official Full Name
zinc transporter 10
NCBI Official Synonym Full Names
solute carrier family 30, member 10
NCBI Protein Information
zinc transporter 10
UniProt Protein Name
Zinc transporter 10
UniProt Synonym Protein Names
Solute carrier family 30 member 10
UniProt Synonym Gene Names
UniProt Comments for Slc30a10
Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death. Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells.
Research Articles on Slc30a10
Precautions
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Products associated with Slc30a10 recombinant protein
Diseases associated with Slc30a10 recombinant protein
Organs/Tissues associated with Slc30a10 recombinant protein
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