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BD-4 recombinant protein :: beta Defensin-4 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS553171 BD-4 recombinant protein
Unit / Price
0.005 mg  /  $145 +1 FREE 8GB USB
0.02 mg  /  $220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

beta Defensin-4 (BD-4), Recombinant Protein

 Also Known As   

Human beta Defensin-4 Recombinant

 Product Synonym Names    DEFB104A; bd-4; bd4; beta defensin
 Product Gene Name   

BD-4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MQRLVLLLAI SLLLYQDLPV RSEFELDRIC GYGTARCRKK CRSQEYRIGR CPNTYACCLR KWDESLLNRT KP
 3D Structure    ModBase 3D Structure for Q8WTQ1
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 Host    E Coli
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 Purity/Purification    >98%, as determined by SDS-PAGE and HPLC
 Form/Format    Recombinant Human beta Defensin-4 was lyophilized from 0.2 um filtered 100mM NaCl, 20mM PB, pH 7.4.
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 Domain    defensin
 Host Note    Optimized DNA sequence encoding Human beta Defensin-4 mature chain was expressed in Escherichia Coli.
 Endotoxin    Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
 Reconstitution    A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
 Molecular Weight Note    Native human BD-4 is generated by the proteolytic removal of the signal peptide and propeptide, the molecule has a calculated molecular mass of approximately 6 kDa. Recombinant beta Defensin-4 is a disulfide-linked monomer protein consisting of 51 amino acid residue subunits, and migrates as an approximately 6 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
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 Preparation and Storage    The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of BD-4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for BD-4 recombinant protein

   Defensins are a large family of peptides of which two groups exist in mammals: alpha defensins and beta defensins, which are distinguishable by the spacing and connectivity of the conserved cysteine residues within the mature peptides.It is thought that defensins function in the eradication of pathogens from the host system by inserting themselves into the bacterial membrane under the influence of membrane potential, forming channels which lead to leakage of cytoplasmic molecules and cell death. Unlike hBD-1, this second peptide, human beta-defensin-2 (hBD-2), is regulated at a transcriptional level in response to contact with microorganisms, and is highly eåective in killing the gram negative bacteria Its expression is also upregulated by the cytokine tumor necrosis factor-alpha.
 Product Categories/Family for BD-4 recombinant protein    Cytokines
NCBI/Uniprot data below describe general gene information for BD-4. It may not necessarily be applicable to this product.
 NCBI GI #    103485137
 NCBI GeneID    503618
 NCBI Accession #    NP_001035792.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040702.1 [Other Products]
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 UniProt Primary Accession #    Q8WTQ1 [Other Products]
 UniProt Secondary Accession #    Q496I2; Q496I3; Q496I4 [Other Products]
 UniProt Related Accession #    Q8WTQ1 [Other Products]
 Molecular Weight    8,526 Da
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 NCBI Official Full Name    beta-defensin 104
 UniProt Protein Name    Beta-defensin 104
 UniProt Synonym Protein Names   
Beta-defensin 4; BD-4; DEFB-4; hBD-4; Defensin, beta 104
 UniProt Gene Name    DEFB104A [Similar Products]
 UniProt Synonym Gene Names    DEFB104; DEFB4; BD-4; DEFB-4; hBD-4 [Similar Products]
 UniProt Entry Name    D104A_HUMAN
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 NCBI Summary for BD-4    Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]
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 UniProt Comments for BD-4    defensin, beta 4: Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. Belongs to the beta-defensin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: cell surface; extracellular region

Biological Process: defense response to bacterium; innate immune response
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with BD-4 recombinant protein
 Products by Pathway  Pathway Diagram
 Beta Defensins Pathway antibodies  Beta Defensins Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
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