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b NGF recombinant protein :: beta Nerve Growth Factor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144360 b NGF recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

beta Nerve Growth Factor (b NGF), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human beta Nerve Growth Factor, HEK

 Product Synonym Names    b NGF Human, HEK; beta Nerve Growth Factor Human Recombinant, HEK; Beta Polypeptide; NGF; NGFB; HSAN5; Beta-NGF; MGC161426; MGC161428; b NGF HEK
 Product Gene Name   

b NGF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    162030
 3D Structure    ModBase 3D Structure for P01138
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 Host    HEK
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 Purity/Purification    Greater than 95% as obsereved by SDS-PAGE.
 Form/Format    The b-NGF was lyophilized from 1mg/ml in 1xPBS.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized b-NGF in sterile water not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The specific activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line) and is typically 1.5-8ng/ml.
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 Other Notes    Small volumes of b NGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for b NGF recombinant protein

   Description: Beta-NGF Human Recombinant produced in HEK cells is a non-glycosylated non-disulfide linked homodimer, having a total molecular weight of 13kDa.The b-NGF is purified by proprietary chromatographic techniques.

Introduction: NGF-beta has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.
 Product Categories/Family for b NGF recombinant protein    CYTOKINES AND GROWTH FACTORS; Neurotrophins; Beta-Nerve Growth Factor
NCBI/Uniprot data below describe general gene information for b NGF. It may not necessarily be applicable to this product.
 NCBI GI #    70995319
 NCBI GeneID    4803
 NCBI Accession #    NP_002497.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002506.2 [Other Products]
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 UniProt Primary Accession #    P01138 [Other Products]
 UniProt Secondary Accession #    Q6FHA0; Q96P60; Q9P2Q8; Q9UKL8; A1A4E5 [Other Products]
 UniProt Related Accession #    P01138 [Other Products]
 Molecular Weight    26,959 Da
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 NCBI Official Full Name    beta-nerve growth factor
 NCBI Official Synonym Full Names    nerve growth factor (beta polypeptide)
 NCBI Official Symbol    NGF [Similar Products]
 NCBI Official Synonym Symbols   
NGFB; HSAN5; Beta-NGF
[Similar Products]
 NCBI Protein Information    beta-nerve growth factor; nerve growth factor, beta subunit
 UniProt Protein Name    Beta-nerve growth factor
 UniProt Gene Name    NGF [Similar Products]
 UniProt Synonym Gene Names    NGFB; Beta-NGF [Similar Products]
 UniProt Entry Name    NGF_HUMAN
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 NCBI Summary for b NGF    This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for b NGF    NGF: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: extracellular space; Golgi lumen; cytoplasmic membrane-bound vesicle; extracellular region; endosome

Molecular Function: metalloendopeptidase inhibitor activity; protein binding; nerve growth factor receptor binding; growth factor activity; receptor signaling protein activity

Biological Process: response to nicotine; circadian rhythm; response to peptide hormone stimulus; nerve growth factor receptor signaling pathway; activation of MAPKK activity; positive regulation of apoptosis; regulation of neuron differentiation; adult locomotory behavior; positive regulation of axon extension; response to glucocorticoid stimulus; regulation of neurotransmitter secretion; response to lipopolysaccharide; sensory perception of pain; regulation of caspase activity; regulation of axonogenesis; negative regulation of cell cycle; nerve growth factor processing; response to radiation; cell-cell signaling; small GTPase mediated signal transduction; negative regulation of neuron apoptosis; response to electrical stimulus; inflammatory response; response to drug; positive regulation of neuron maturation; phosphoinositide-mediated signaling; positive regulation of protein amino acid autophosphorylation; memory; positive regulation of nerve growth factor receptor signaling pathway; regulation of release of sequestered calcium ion into cytosol; peripheral nervous system development; neuron apoptosis; induction of apoptosis via death domain receptors; response to mechanical stimulus; phospholipase C activation; response to ozone; Ras protein signal transduction; positive regulation of axonogenesis; positive regulation of transcription factor activity; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis; negative regulation of apoptosis

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type V
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 Research Articles on b NGF    1. Increased NGF expression is associated with spontaneous abortions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with b NGF recombinant proteinPathways associated with b NGF recombinant protein
 Reference Product  PubMed Publications
 NTRK1 recombinant protein  >2032 publications with b NGF and NTRK1
 NGFR recombinant protein  >241 publications with b NGF and NGFR
 CASP3 recombinant protein  >178 publications with b NGF and CASP3
 TRPV1 recombinant protein  >95 publications with b NGF and TRPV1
 SHC1 recombinant protein  >26 publications with b NGF and SHC1
 PLG recombinant protein  >7 publications with b NGF and PLG
 GIPC1 recombinant protein  >2 publications with b NGF and GIPC1
 SORCS3 recombinant protein  >1 publications with b NGF and SORCS3
 MMP7 recombinant protein  >1 publications with b NGF and MMP7
 SORT1 recombinant protein  >1 publications with b NGF and SORT1
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activation Of TRKA Receptors Pathway antibodies  Activation Of TRKA Receptors Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Ceramide Signalling Pathway antibodies  Ceramide Signalling Pathway Diagram
 Frs2-mediated Activation Pathway antibodies  Frs2-mediated Activation Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
Diseases associated with b NGF recombinant proteinOrgans/Tissues associated with b NGF recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2217 publications with b NGF and Nervous System Diseases
 Pain Antibodies  >764 publications with b NGF and Pain
 Neurodegenerative Diseases Antibodies  >736 publications with b NGF and Neurodegenerative Diseases
 Inflammation Antibodies  >699 publications with b NGF and Inflammation
 Nerve Degeneration Antibodies  >612 publications with b NGF and Nerve Degeneration
 Peripheral Nervous System Diseases Antibodies  >466 publications with b NGF and Peripheral Nervous System Diseases
 Necrosis Antibodies  >447 publications with b NGF and Necrosis
 Hyperalgesia Antibodies  >318 publications with b NGF and Hyperalgesia
 Heart Diseases Antibodies  >126 publications with b NGF and Heart Diseases
 Memory Disorders Antibodies  >113 publications with b NGF and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >660 publications with b NGF and Muscle
 Embryonic Tissue Antibodies  >613 publications with b NGF and Embryonic Tissue
 Skin Antibodies  >532 publications with b NGF and Skin
 Eye Antibodies  >432 publications with b NGF and Eye
 Lung Antibodies  >175 publications with b NGF and Lung
 Intestine Antibodies  >113 publications with b NGF and Intestine
 Spleen Antibodies  >92 publications with b NGF and Spleen
 Uncharacterized Tissue Antibodies  >1 publications with b NGF and Uncharacterized Tissue
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