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SNCB recombinant protein :: beta-Synuclein Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203010
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

beta-Synuclein (SNCB), Recombinant Protein

 Also Known As   

beta-Synuclein, 1-134aa, Human, E Coli

 Product Synonym Names    Beta-synuclein; SNCB beta-Synuclein; B-synuclein; Beta synuclein; beta synuclein; Phosphoneuroprotein 14; PNP14; Synuclein beta
 Product Gene Name   

SNCB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    S69965 mRNA
 3D Structure    ModBase 3D Structure for Q16143
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 0.1 M NaCl, 1mM MgCl2
 Concentration    1 mg/ml (determined by BCA assay) (lot specific)
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 Antigen Species    Human
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of SNCB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SNCB recombinant protein

   beta-synuclein (amino acids 1-134), an acidic neuronal protein of 134 amino acids, is extremely heat-resistant. beta-synucelin also has a chaperone-like activity. Recently, beta-synuclein has been suggested to inhibit
 Product Categories/Family for SNCB recombinant protein    Neuroscience
 Applications Tested/Suitable for SNCB recombinant protein   


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 SDS-Page of SNCB recombinant protein    SNCB recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for SNCB. It may not necessarily be applicable to this product.
 NCBI GI #    48255903
 NCBI GeneID    6620
 NCBI Accession #    NP_001001502.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001001502.2 [Other Products]
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 UniProt Primary Accession #    Q16143 [Other Products]
 UniProt Secondary Accession #    Q6IAX7 [Other Products]
 UniProt Related Accession #    Q16143 [Other Products]
 Molecular Weight    14.2 kDa (134 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher) [Similar Products]
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 NCBI Official Full Name    beta-synuclein isoform 1
 NCBI Official Synonym Full Names    synuclein beta
 NCBI Official Symbol    SNCB [Similar Products]
 NCBI Protein Information    beta-synuclein
 UniProt Protein Name    Beta-synuclein
 Protein Family    Beta-synuclein
 UniProt Gene Name    SNCB [Similar Products]
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 NCBI Summary for SNCB    This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
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 UniProt Comments for SNCB    Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
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Product References and Citations for SNCB recombinant protein

   Jakes R., et al. (1994) FEBS lett. 345, 27-32.; Kim J.,et al. (1997) Molecules and Cells. 7, 78-83.; Hashimoto M., et al. (2001) Neuron 32, 213-223.;
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 Research Articles on SNCB    1. Data suggest that pH serves as an on/off switch for beta- synuclein to form aggregates/fibrils (as seem in Parkinson disease); hydrogen bonding between glutamate residues appears to be involved in fibril formation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SNCB recombinant proteinDiseases associated with SNCB recombinant protein
 Reference Product  PubMed Publications
 SNAP25 recombinant protein  >2 publications with SNCB and SNAP25
 APP recombinant protein  >2 publications with SNCB and APP
 UCHL1 recombinant protein  >2 publications with SNCB and UCHL1
 SNCAIP recombinant protein  >2 publications with SNCB and SNCAIP
 Disease Name  Pubmed Publications
 Lewy Body Disease Antibodies  >21 publications with SNCB and Lewy Body Disease
 Disease Models, Animal Antibodies  >9 publications with SNCB and Disease Models, Animal
 Nerve Degeneration Antibodies  >7 publications with SNCB and Nerve Degeneration
 Hyperplasia Antibodies  >4 publications with SNCB and Hyperplasia
 Neurobehavioral Manifestations Antibodies  >2 publications with SNCB and Neurobehavioral Manifestations
 Fibrosis Antibodies  >2 publications with SNCB and Fibrosis
 Depressive Disorder Antibodies  >1 publications with SNCB and Depressive Disorder
 Neurotoxicity Syndromes Antibodies  >1 publications with SNCB and Neurotoxicity Syndromes
 Kidney Diseases Antibodies  >1 publications with SNCB and Kidney Diseases
 Poisoning Antibodies  >1 publications with SNCB and Poisoning
Organs/Tissues associated with SNCB recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >73 publications with SNCB and Nerve
 Brain Antibodies  >68 publications with SNCB and Brain
 Eye Antibodies  >1 publications with SNCB and Eye
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