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PKAr-1a recombinant protein :: c-AMP dependant Protein Kinase A regulatory subunit 2 alpha Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142750 PKAr-1a recombinant protein
Unit / Price
0.001 mg  /  $140 +1 FREE 8GB USB
0.003 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $3,625 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-AMP dependant Protein Kinase A regulatory subunit 2 alpha (PKAr-1a), Recombinant Protein

 Also Known As   

Recombinant c-AMP dependant Protein Kinase A regulatory subunit 2 alpha

 Product Synonym Names    PKA-RII alpha; cAMP-Dependent Protein Kinase A regulatory subunit-II A Recombinant; cAMP-Dependent Protein Kinase A regulatory subunit-II A; PKA-RII alpha
 Product Gene Name   

PKAr-1a recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPRVIH PKTDEQRCRL QEACKDILLF KNLDQEQLSQ VLDAMFERIV KADEHVIDQG DDGDNFYVIE RGTYDILVTK DNQTRSVGQY DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI IVKNNAKKRK MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QGEKADSFYI IESGEVSILI RSRTKSNKDG GNQEVEIARC HKGQYFGELA LVTNKPRAAS AYAVGDVKCL VMDVQAFERL LGPCMDIMKR NISHYEEQLV KMFGSSVDLG NLGQ
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    PKA regulatory subunit-II alpha is supplied at a concentration of 0.37mg/ml in 20mM MES, 150mM NaCl, 2mM EDTA, 2mM EGTA, 1mM BME and 50% glycerol.
Sterile Filtered clear solution.
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 Inhibitory Activity    The cAMP-Dependent Protein Kinase, regulatory subunit RIIa reversibly inhibits the catalytic subunit Ca of the cAMP-dependent protein kinase PKA. The inhibition of the catalytic subunit can be reversed by the addition of the second messenger cAMP (> 1uM)
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 Preparation and Storage    PKA should be stored at 4 degree C if entire vial will be used within 1 week. For long term storage below -20 degree C.Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of PKAr-1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PKAr-1a recombinant protein

   Description: The recombinant PKA regulatory subunit II-a is a dimeric 90 kDa protein. Protein Kinase A is purified by proprietary chromatographic techniques.

Introduction: cAMP-dependent PKA is a ubiquitous serine/theonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart). The intracellular cAMP level regulates cellular responses by altering the interaction between the catatytic C and regulatory R subunits of PKA. The inactive tetrameric PKA holoenzyme R2C2 is activated when cAMP binds to R2, which dissociates the tetramer to R2 cAMP 4 and two active catalytic subunits. Free Catalytic subunits of PKA can phosphorylate a wide variety of intracellular target proteins. In response to hormone- induced high cAMP levels, PKA phosphorylates glycogen synthetase (inhibition of the enzyme activity) and phosphorylase kinase to block glycogen synthesis. Different isoforms of catalytic and regulatory subunits suggest specific functions.
 Product Categories/Family for PKAr-1a recombinant protein    PROTEIN KINASES; Enzymes; Protein Kinase-A
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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