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c-Jun recombinant protein

Scan QR to view Datasheet Catalog #    MBS204023
SDS-Page
Unit / Price
0.01 mg  /  $310 +1 FREE 8GB USB
0.05 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-Jun, Recombinant Protein

★Popular Item★
 Also Known As   

c-Jun, 1-241aa, Human, His tag, E Coli

 Product Synonym Names    Transcription factor AP-1; AP-1; AP1; c-Jun; jun proto-oncogene
 Product Gene Name   

c-Jun recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK PHLRAKNSDL LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE LHSQNTLPSV TSAAQPVNGA GMVAPAVASV AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA LSSGGGAPSY GAAGLAFPAQ PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP P
 OMIM    J04111 Genomic DNA
 3D Structure    ModBase 3D Structure for P05412
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.
 Concentration    0.25 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of c-Jun recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for c-Jun recombinant protein

   The human protooncogene c-Jun is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. c-Jun and c-Fos form a complex in the nucleus. AP1 is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21, p19 and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. Recombinant human c-Jun protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for c-Jun recombinant protein    Cancer
 Applications Tested/Suitable for c-Jun recombinant protein   

SDS-PAGE

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 SDS-Page of c-Jun recombinant protein    c-Jun recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for c-Jun. It may not necessarily be applicable to this product.
 NCBI GI #    4758616
 NCBI GeneID    3725
 NCBI Accession #    NP_002219 [Other Products]
 NCBI GenBank Nucleotide #    NM_002228.3 [Other Products]
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 UniProt Primary Accession #    P05412 [Other Products]
 UniProt Secondary Accession #    Q6FHM7; Q96G93 [Other Products]
 UniProt Related Accession #    P05412 [Other Products]
 Molecular Weight    27.3 kDa (261 aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    transcription factor AP-1
 NCBI Official Synonym Full Names    Jun proto-oncogene, AP-1 transcription factor subunit
 NCBI Official Symbol    JUN [Similar Products]
 NCBI Official Synonym Symbols   
AP1; p39; AP-1; c-Jun
[Similar Products]
 NCBI Protein Information    transcription factor AP-1
 UniProt Protein Name    Transcription factor AP-1
 UniProt Synonym Protein Names   
Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
 Protein Family    C-Jun-amino-terminal kinase-interacting protein
 UniProt Gene Name    JUN [Similar Products]
 UniProt Synonym Gene Names    AP1 [Similar Products]
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 NCBI Summary for c-Jun    This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
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 UniProt Comments for c-Jun    Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
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Product References and Citations for c-Jun recombinant protein

   Bohmann D., et al. (1987) Science. 238 (4832):1386-92. ; Bannister AJ., et al. (1993) Nucleic Acids Res. 21 (5):1289-95.
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 Research Articles on c-Jun    1. The positive feedback regulation of OCT4 and c-JUN, resulting in the continuous expression of oncogenes such as c-JUN, seems to play a critical role in the determination of the cell fate decision from induced pluripotent stem cells to cancer stem cells in liver cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with c-Jun recombinant proteinPathways associated with c-Jun recombinant protein
 Reference Product  PubMed Publications
 FOS recombinant protein  >8705 publications with c-Jun and FOS
 MAPK8 recombinant protein  >917 publications with c-Jun and MAPK8
 FOSB recombinant protein  >371 publications with c-Jun and FOSB
 ATF3 recombinant protein  >257 publications with c-Jun and ATF3
 MAPK1 recombinant protein  >235 publications with c-Jun and MAPK1
 FOSL2 recombinant protein  >116 publications with c-Jun and FOSL2
 NFATC2 recombinant protein  >51 publications with c-Jun and NFATC2
 FOSL1 recombinant protein  >31 publications with c-Jun and FOSL1
 MAPK9 recombinant protein  >17 publications with c-Jun and MAPK9
 MAPK10 recombinant protein  >10 publications with c-Jun and MAPK10
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 Activation Of HOX Genes During Differentiation Pathway antibodies  Activation Of HOX Genes During Differentiation Pathway Diagram
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Diseases associated with c-Jun recombinant proteinOrgans/Tissues associated with c-Jun recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >196959 publications with c-Jun and Nervous System Diseases
 Brain Diseases Antibodies  >98081 publications with c-Jun and Brain Diseases
 Heart Diseases Antibodies  >93187 publications with c-Jun and Heart Diseases
 Inflammation Antibodies  >52687 publications with c-Jun and Inflammation
 Liver Diseases Antibodies  >50139 publications with c-Jun and Liver Diseases
 Kidney Diseases Antibodies  >42464 publications with c-Jun and Kidney Diseases
 Disease Models, Animal Antibodies  >41621 publications with c-Jun and Disease Models, Animal
 Hypertension Antibodies  >39468 publications with c-Jun and Hypertension
 Necrosis Antibodies  >33113 publications with c-Jun and Necrosis
 Hemorrhage Antibodies  >32081 publications with c-Jun and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >338829 publications with c-Jun and Blood
 Brain Antibodies  >144815 publications with c-Jun and Brain
 Heart Antibodies  >113750 publications with c-Jun and Heart
 Vascular Antibodies  >102722 publications with c-Jun and Vascular
 Bone Antibodies  >98814 publications with c-Jun and Bone
 Liver Antibodies  >88467 publications with c-Jun and Liver
 Muscle Antibodies  >85153 publications with c-Jun and Muscle
 Lung Antibodies  >69367 publications with c-Jun and Lung
 Kidney Antibodies  >65417 publications with c-Jun and Kidney
 Skin Antibodies  >62924 publications with c-Jun and Skin
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