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Prkar1a recombinant protein :: cAMP-dependent protein kinase type I-alpha regulatory subunit (Prkar1a) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950497 Prkar1a recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $795 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,035 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,060 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,170 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,215 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,280 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,310 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,375 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,660 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,885 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,940 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,090 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,505 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cAMP-dependent protein kinase type I-alpha regulatory subunit (Prkar1a), Recombinant Protein

 Also Known As   

Recombinant Rat cAMP-dependent protein kinase type I-alpha regulatory subunit (Prkar1a)

 Product Gene Name   

Prkar1a recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-381aa, Full length protein
 Sequence    MASGSMAASE EERSLRECEL YVQKHNIQAL LKDSIVQLCT ARPERPMAFL REYFERLEKE EARQIQSLQK SGIRTDSRED EISPPPPNPV VKGRRRRGAI SAEVYTEEDA ASYVRKVIPK DYKTMAALAK AIEKNVLFSH LDDNERSDIF DAMFPVSFIA GETVIQQGDE GDNFYVIDQG EMDVYVNNEW ATSVGEGGSF GELALIYGTP RAATVKAKTN VKLWGIDRDS YRRILMGSTL RKRKMYEEFL SKVSILESLD KWERLTVADA LEPVQFEDGQ KIVVQGEPGD EFFIILEGTA AVLQRRSENE EFVEVGRLGP SDYFGEIALL MNRPRAATVV ARGPLKCVKL DRPRFERVLG PCSDILKRNI QQYNSFVSLS V
 3D Structure    ModBase 3D Structure for P09456
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rat
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Prkar1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Prkar1a recombinant protein

   cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.
NCBI/Uniprot data below describe general gene information for Prkar1a. It may not necessarily be applicable to this product.
 NCBI GI #    6981396
 NCBI GeneID    25725
 NCBI Accession #    NP_037313.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013181.1 [Other Products]
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 UniProt Primary Accession #    P09456 [Other Products]
 UniProt Related Accession #    P09456 [Other Products]
 Molecular Weight    43,095 Da
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 NCBI Official Full Name    cAMP-dependent protein kinase type I-alpha regulatory subunit
 NCBI Official Synonym Full Names    protein kinase cAMP-dependent type 1 regulatory subunit alpha
 NCBI Official Symbol    Prkar1a [Similar Products]
 NCBI Official Synonym Symbols   
RIIA
[Similar Products]
 NCBI Protein Information    cAMP-dependent protein kinase type I-alpha regulatory subunit
 UniProt Protein Name    cAMP-dependent protein kinase type I-alpha regulatory subunit
 Protein Family    cAMP-dependent protein kinase
 UniProt Gene Name    Prkar1a [Similar Products]
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 NCBI Summary for Prkar1a    regulatory subunit of cAMP-dependent protein kinase (PKA); negatively regulates meiosis [RGD, Feb 2006]
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 UniProt Comments for Prkar1a    Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
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 Research Articles on Prkar1a    1. role for PKA signaling in both short- and long-term regulation of AQP2, characterizing a novel mouse model of diabetes insipidus
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Prkar1a recombinant proteinPathways associated with Prkar1a recombinant protein
 Reference Product  PubMed Publications
 Prkar2a recombinant protein  >30 publications with Prkar1a and Prkar2a
 Prkar2b recombinant protein  >27 publications with Prkar1a and Prkar2b
 Prkar1b recombinant protein  >15 publications with Prkar1a and Prkar1b
 Prkaca recombinant protein  >7 publications with Prkar1a and Prkaca
 Akap1 recombinant protein  >4 publications with Prkar1a and Akap1
 Prkacb recombinant protein  >4 publications with Prkar1a and Prkacb
 Rfc2 recombinant protein  >2 publications with Prkar1a and Rfc2
 Akap10 recombinant protein  >1 publications with Prkar1a and Akap10
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
Diseases associated with Prkar1a recombinant proteinOrgans/Tissues associated with Prkar1a recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >180 publications with Prkar1a and Neoplasms
 Carney Complex Antibodies  >139 publications with Prkar1a and Carney Complex
 Hyperplasia Antibodies  >44 publications with Prkar1a and Hyperplasia
 Adenoma Antibodies  >39 publications with Prkar1a and Adenoma
 Central Nervous System Diseases Antibodies  >39 publications with Prkar1a and Central Nervous System Diseases
 Carcinoma Antibodies  >26 publications with Prkar1a and Carcinoma
 Congenital Abnormalities Antibodies  >25 publications with Prkar1a and Congenital Abnormalities
 Skin Neoplasms Antibodies  >25 publications with Prkar1a and Skin Neoplasms
 PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1 Antibodies  >24 publications with Prkar1a and PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1
 Neoplasms, Hormone-Dependent Antibodies  >23 publications with Prkar1a and Neoplasms, Hormone-Dependent
 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >43 publications with Prkar1a and Adrenal Gland
 Heart Antibodies  >34 publications with Prkar1a and Heart
 Pituitary Gland Antibodies  >17 publications with Prkar1a and Pituitary Gland
 Brain Antibodies  >16 publications with Prkar1a and Brain
 Embryonic Tissue Antibodies  >14 publications with Prkar1a and Embryonic Tissue
 Liver Antibodies  >10 publications with Prkar1a and Liver
 Lung Antibodies  >9 publications with Prkar1a and Lung
 Prostate Antibodies  >6 publications with Prkar1a and Prostate
 Kidney Antibodies  >5 publications with Prkar1a and Kidney
 Nerve Antibodies  >5 publications with Prkar1a and Nerve
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