NP_001012750.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,014 Da
NCBI Official Full Name
deoxycytidylate deaminase isoform a
NCBI Official Synonym Full Names
dCMP deaminase
NCBI Protein Information
deoxycytidylate deaminase
UniProt Protein Name
Deoxycytidylate deaminase
UniProt Synonym Protein Names
dCMP deaminase
UniProt Entry Name
DCTD_HUMAN
NCBI Summary for DCTD
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for DCTD
DCTD: catalyzes the deamination of dCMP to dUMP, thus providing the nucleotide substrate for thymidylate synthase. Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.
Protein type: Nucleotide Metabolism - pyrimidine; EC 3.5.4.12; Hydrolase
Chromosomal Location of Human Ortholog: 4q35.1
Cellular Component: cytosol
Molecular Function: zinc ion binding; dCMP deaminase activity
Biological Process: pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleotide metabolic process; nucleotide biosynthetic process; pyrimidine nucleoside biosynthetic process
Research Articles on DCTD
Precautions
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Products associated with DCTD recombinant protein
Pathways associated with DCTD recombinant protein
Diseases associated with DCTD recombinant protein
Organs/Tissues associated with DCTD recombinant protein
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