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NTHL1 recombinant protein :: nth Endonuclease III-Like 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145085 NTHL1 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $5,015 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

nth Endonuclease III-Like 1 (NTHL1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human nth Endonuclease III-Like 1

 Product Synonym Names    NTHL1 Human; Nth Endonuclease III-Like 1 Human Recombinant; Endonuclease III-like protein 1; NTHL1; NTH1; OCTS3
 Product Gene Name   

NTHL1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MCSPQESGMT ALSARMLTRS RSLGPGAGPR GCREEPGPLR RREAAAEARK SHSPVKRPRK AQRLRVAYEG SDSEKGEGAE PLKVPVWEPQ DWQQQLVNIR AMRNKKDAPV DHLGTEHCYD SSAPPKVRRY QVLLSLMLSS QTKDQVTAGA MQRLRARGLT VDSILQTDDA TLGKLIYPVG FWRSKVKYIK QTSAILQQHY GGDIPASVAE LVALPGVGPK MAHLAMAVAW GTVSGIAVDT HVHRIANRLR WTKKATKSPE ETRAALEEWL PRELWHEING LLVGFGQQTC LPVHPRCHAC LNQALCPAAQ GL
 OMIM    602656
 3D Structure    ModBase 3D Structure for P78549
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 Host    E Coli
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 Purity/Purification    Greater than 80.0% as determined by SDS-PAGE.
 Form/Format    NTHL1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.15M NaCl and 1mM DTT.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of NTHL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NTHL1 recombinant protein

   Description: NTHL1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 332 amino acids (1-312 a.a.) and having a molecular mass of 36.6kDa.NTHL1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Nth endonuclease III-like protein 1 (NTHL1) is one of the enzymes which act on a large number of oxidatively damaged DNA sites. NTHL1 has an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. NTHL1 acts on a damaged strand, 5' from the damaged site and incises damaged DNA at cytosines, thymines and guanines.
 Product Categories/Family for NTHL1 recombinant protein    ENZYMES; Enzymes; Endonuclease
NCBI/Uniprot data below describe general gene information for NTHL1. It may not necessarily be applicable to this product.
 NCBI GI #    4505471
 NCBI GeneID    4913
 NCBI Accession #    NP_002519.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002528.5 [Other Products]
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 UniProt Primary Accession #    P78549 [Other Products]
 UniProt Secondary Accession #    Q1MVR1; Q99566; Q99794; Q9BPX2 [Other Products]
 UniProt Related Accession #    P78549 [Other Products]
 Molecular Weight    32,839 Da
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 NCBI Official Full Name    endonuclease III-like protein 1
 NCBI Official Synonym Full Names    nth endonuclease III-like 1 (E. coli)
 NCBI Official Symbol    NTHL1 [Similar Products]
 NCBI Official Synonym Symbols   
NTH1; OCTS3; hNTH1
[Similar Products]
 NCBI Protein Information    endonuclease III-like protein 1; DNA glycoslyase/AP lyase; NTHL1; bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase
 UniProt Protein Name    Endonuclease III-like protein 1
 UniProt Synonym Protein Names   
Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase
 Protein Family    Endonuclease III-like protein
 UniProt Gene Name    NTHL1 [Similar Products]
 UniProt Synonym Gene Names    hNTH1 [Similar Products]
 UniProt Entry Name    NTH_HUMAN
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 NCBI Summary for NTHL1    The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
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 UniProt Comments for NTHL1    NTHL1: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions. Belongs to the Nth/MutY family.

Protein type: DNA repair, damage; Hydrolase; Mitochondrial; EC 4.2.99.18; Lyase

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nucleoplasm; mitochondrion; nucleus

Molecular Function: protein binding; DNA-(apurinic or apyrimidinic site) lyase activity; endonuclease activity; metal ion binding; 4 iron, 4 sulfur cluster binding; double-stranded DNA binding; DNA N-glycosylase activity

Biological Process: base-excision repair, AP site formation; base-excision repair; depyrimidination; DNA repair; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA catabolic process, endonucleolytic

Disease: Familial Adenomatous Polyposis 3
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 Research Articles on NTHL1    1. we demonstrated that hNEIL1 and hNTH1 cleave Oz sites as efficiently as 5-hydroxyuracil sites. Thus, hNEIL1 and hNTH1 can repair Oz lesions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NTHL1 recombinant proteinPathways associated with NTHL1 recombinant protein
 Reference Product  PubMed Publications
 NEIL1 recombinant protein  >18 publications with NTHL1 and NEIL1
 OGG1 recombinant protein  >16 publications with NTHL1 and OGG1
 NEIL2 recombinant protein  >9 publications with NTHL1 and NEIL2
 APEX1 recombinant protein  >6 publications with NTHL1 and APEX1
 NUDT1 recombinant protein  >3 publications with NTHL1 and NUDT1
 YBX1 recombinant protein  >2 publications with NTHL1 and YBX1
 XPA recombinant protein  >1 publications with NTHL1 and XPA
 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base-Excision Repair, AP Site Formation Pathway antibodies  Base-Excision Repair, AP Site Formation Pathway Diagram
 Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway antibodies  Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway Diagram
 Cleavage Of The Damaged Pyrimidine Pathway antibodies  Cleavage Of The Damaged Pyrimidine Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Depyrimidination Pathway antibodies  Depyrimidination Pathway Diagram
 Displacement Of DNA Glycosylase By APE1 Pathway antibodies  Displacement Of DNA Glycosylase By APE1 Pathway Diagram
 Recognition And Association Of DNA Glycosylase With Site Containing An Affected Pyrimidine Pathway antibodies  Recognition And Association Of DNA Glycosylase With Site Containing An Affected Pyrimidine Pathway Diagram
Diseases associated with NTHL1 recombinant proteinOrgans/Tissues associated with NTHL1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with NTHL1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >4 publications with NTHL1 and Congenital Abnormalities
 Neoplasms, Experimental Antibodies  >2 publications with NTHL1 and Neoplasms, Experimental
 Brain Diseases Antibodies  >2 publications with NTHL1 and Brain Diseases
 Ovarian Neoplasms Antibodies  >2 publications with NTHL1 and Ovarian Neoplasms
 Death Antibodies  >2 publications with NTHL1 and Death
 Kidney Diseases Antibodies  >2 publications with NTHL1 and Kidney Diseases
 Lung Diseases Antibodies  >2 publications with NTHL1 and Lung Diseases
 Liver Neoplasms Antibodies  >1 publications with NTHL1 and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with NTHL1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with NTHL1 and Blood
 Kidney Antibodies  >3 publications with NTHL1 and Kidney
 Liver Antibodies  >3 publications with NTHL1 and Liver
 Lung Antibodies  >3 publications with NTHL1 and Lung
 Lymph Antibodies  >1 publications with NTHL1 and Lymph
 Pharynx Antibodies  >1 publications with NTHL1 and Pharynx
 Muscle Antibodies  >1 publications with NTHL1 and Muscle
 Testis Antibodies  >1 publications with NTHL1 and Testis
 Stomach Antibodies  >1 publications with NTHL1 and Stomach
 Brain Antibodies  >1 publications with NTHL1 and Brain
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