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p16-INK4a recombinant protein

Scan QR to view Datasheet Catalog #    MBS695976
Testing Data
Unit / Price
0.005 mg  /  $125 +1 FREE 8GB USB
0.02 mg  /  $195 +1 FREE 8GB USB
0.1 mg  /  $640 +1 FREE 8GB USB
0.5 mg  /  $1,820 +2 FREE 8GB USB
1 mg  /  $2,980 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

p16-INK4a, Recombinant Protein

★Popular Item★
 Also Known As   

Human p16-INK4a

 Product Synonym Names    Recombinant Human p16-INK4a
 Product Gene Name   

p16-INK4a recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MEPAAGSSM EPSADWLAT AAARGRVEE VRALLEAGA LPNAPNSYG RRPIQVMMM GSARVAELL LLHGAEPNC ADPATLTRP VHDAAREGF LDTLVVLHR AGARLDVRD AWGRLPVDL AEELGHRDV ARYLRAAAG GTRGSNHAR IDAAEGPSD IPD
 OMIM    gene 606719
 3D Structure    ModBase 3D Structure for P42771
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 Host    E Coli
 Species Reactivity    Species Reactivity: Human
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 Purity/Purification    Above 95% as determined by SDS-PAGE Analysis.
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 Cell Type    Stem Cells
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 Preparation and Storage    At -20 degree C
 Other Notes    Small volumes of p16-INK4a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for p16-INK4a recombinant protein

   p16-INK4a is a nuclear protein that regulates the cell cycle by inhibiting cyclin dependent kinase-4 (CDK4) and CDK6. p16-INK4a inhibits CDK activity by binding to the CDK molecules in a manner that interferes with their ability to interact with cyclin D. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of p16-INK4a steadily increases with age and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the p16-INK4a gene is frequently found in melanomas as well as in certain other types of cancer. Recombinant p16-INK4a is a 16.5 kDa protein containing 156 amino acid residues.
 Product Categories/Family for p16-INK4a recombinant protein    Stem Cell Research; Cancer
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 Testing Data of p16-INK4a recombinant protein    p16-INK4a recombinant protein Testing Data image
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NCBI/Uniprot data below describe general gene information for p16-INK4a. It may not necessarily be applicable to this product.
 NCBI GI #    3041660
 NCBI GeneID    1029
 NCBI Accession #    P42771.2 [Other Products]
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 UniProt Primary Accession #    P42771 [Other Products]
 UniProt Secondary Accession #    O95440; Q15191; Q5VVJ5; Q96B52; Q9NP05; A5X2G7; D3DRK1 [Other Products]
 UniProt Related Accession #    P42771; Q8N726 [Other Products]
 Molecular Weight    8,731 Da
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 NCBI Official Full Name    Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
 NCBI Official Synonym Full Names    cyclin-dependent kinase inhibitor 2A
 NCBI Official Symbol    CDKN2A [Similar Products]
 NCBI Official Synonym Symbols   
ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase inhibitor 2A; CDKN2A; CDK4 inhibitor p16-INK4; multiple tumor suppressor 1; cell cycle negative regulator beta; cyclin-dependent kinase 4 inhibitor A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
 UniProt Protein Name    Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
 UniProt Synonym Protein Names   
Cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4A
 UniProt Gene Name    CDKN2A [Similar Products]
 UniProt Synonym Gene Names    CDKN2; MTS1; CDK4I; MTS-1; p16-INK4; p16INK4A [Similar Products]
 UniProt Entry Name    CD2A1_HUMAN
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 NCBI Summary for p16-INK4a    This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
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 UniProt Comments for p16-INK4a    p16-INK4A: a cell-cycle regulatory protein that interacts with CDK4 and CDK6, inhibiting their ability to interact with cyclins D. Inhibits the phosphorylation of the retinoblastoma protein by CDK4 or CDK6, and entry into the S phase of the cell cycle. The p16INK4A and p14ARF proteins are encoded by CDKN2A, a known tumour suppressor gene in multiple cancers. CDKN2A is inactivated in 72% of cases of lung squamous cell carcinoma: 21% by epigenetic silencing by methylation, 18% inactivating mutation, 4% by exon 1b skipping, and 29% by homozygous deletion. Defects in CDKN2A are the cause of familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, Li-Fraumeni syndrome, and the melanoma-astrocytoma syndrome. The melanoma-astrocytoma syndrome is characterized by a dual predisposition to melanoma and neural system tumors, commonly astrocytoma. Four alternatively spliced p16 isoforms have been reported. Two alternatively spliced isoforms of ARF have been reported.

Protein type: Tumor suppressor; Cell cycle regulation; Nucleolus

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: nucleoplasm; nuclear body; protein complex; mitochondrion; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; NF-kappaB binding; protein binding; DNA binding; p53 binding; ubiquitin-protein ligase inhibitor activity; protein kinase binding; transcription factor binding

Biological Process: protein polyubiquitination; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; regulation of protein stability; negative regulation of B cell proliferation; regulation of protein export from nucleus; negative regulation of cell proliferation; apoptotic mitochondrial changes; regulation of G2/M transition of mitotic cell cycle; somatic stem cell division; cell cycle arrest; caspase activation; negative regulation of immature T cell proliferation in the thymus; transcription, DNA-dependent; protein destabilization; protein stabilization; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cell-matrix adhesion; positive regulation of protein sumoylation; inhibition of NF-kappaB transcription factor; Ras protein signal transduction; negative regulation of ubiquitin-protein ligase activity; negative regulation of phosphorylation; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth; positive regulation of DNA damage response, signal transduction by p53 class mediator; mitotic cell cycle; negative regulation of transcription, DNA-dependent; rRNA processing; G1/S transition of mitotic cell cycle

Disease: Melanoma-astrocytoma Syndrome; Melanoma, Cutaneous Malignant, Susceptibility To, 2; Melanoma-pancreatic Cancer Syndrome
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 Research Articles on p16-INK4a    1. Study demonstrated that the CDKN2A/CDKN2B gene may be nominally associated with the efficacy of glibenclamide, and that CDKN2A/CDKN2B is associated with beta cell function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with p16-INK4a recombinant proteinPathways associated with p16-INK4a recombinant protein
 Reference Product  PubMed Publications
 CDK4 recombinant protein  >1001 publications with p16-INK4a and CDK4
 CCND1 recombinant protein  >873 publications with p16-INK4a and CCND1
 TP53 recombinant protein  >654 publications with p16-INK4a and TP53
 MYC recombinant protein  >447 publications with p16-INK4a and MYC
 MDM2 recombinant protein  >369 publications with p16-INK4a and MDM2
 CDK6 recombinant protein  >306 publications with p16-INK4a and CDK6
 CDK2 recombinant protein  >271 publications with p16-INK4a and CDK2
 NPM1 recombinant protein  >4 publications with p16-INK4a and NPM1
 UBC recombinant protein  >1 publications with p16-INK4a and UBC
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
Diseases associated with p16-INK4a recombinant proteinOrgans/Tissues associated with p16-INK4a recombinant protein
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1267 publications with p16-INK4a and Adenocarcinoma
 Urogenital Neoplasms Antibodies  >1189 publications with p16-INK4a and Urogenital Neoplasms
 Cell Transformation, Neoplastic Antibodies  >736 publications with p16-INK4a and Cell Transformation, Neoplastic
 Lymphoma Antibodies  >694 publications with p16-INK4a and Lymphoma
 Lung Neoplasms Antibodies  >663 publications with p16-INK4a and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >621 publications with p16-INK4a and Neoplasms, Experimental
 Glioma Antibodies  >488 publications with p16-INK4a and Glioma
 Pancreatic Neoplasms Antibodies  >444 publications with p16-INK4a and Pancreatic Neoplasms
 Breast Neoplasms Antibodies  >427 publications with p16-INK4a and Breast Neoplasms
 Brain Neoplasms Antibodies  >422 publications with p16-INK4a and Brain Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >915 publications with p16-INK4a and Blood
 Skin Antibodies  >806 publications with p16-INK4a and Skin
 Lung Antibodies  >802 publications with p16-INK4a and Lung
 Brain Antibodies  >506 publications with p16-INK4a and Brain
 Liver Antibodies  >472 publications with p16-INK4a and Liver
 Bone Antibodies  >380 publications with p16-INK4a and Bone
 Lymph Node Antibodies  >329 publications with p16-INK4a and Lymph Node
 Lymph Antibodies  >327 publications with p16-INK4a and Lymph
 Stomach Antibodies  >299 publications with p16-INK4a and Stomach
 Cervix Antibodies  >243 publications with p16-INK4a and Cervix
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