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p38a/SAPK2a recombinant protein :: p38 alpha/SAPK2 alpha Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142763 p38a/SAPK2a recombinant protein
Unit / Price
0.001 mg  /  $205 +1 FREE 8GB USB
0.005 mg  /  $455 +1 FREE 8GB USB
0.02 mg  /  $1,075 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

p38 alpha/SAPK2 alpha (p38a/SAPK2a), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human p38 alpha/SAPK2 alpha

 Product Synonym Names    p38a/SAPK2 Human; p38a/SAPK2 Human Recombinant; Mitogen-activated protein kinase 14; EC 2.7.11.24; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A; RK; p38; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; p38ALPHA
 Product Gene Name   

p38a/SAPK2a recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600289
 3D Structure    ModBase 3D Structure for Q16539
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    p38/SAPK2 is supplied 1.19mg/ml in 25mM Tris-HCl, 150mM NaCl, 1mM DTT, 50% glycerol, pH 8.5.
Sterile Filtered clear solution.
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 Unit Defenition    No protease activity detectable, specific activity is 2.357.900 U*/mg (*1 U = 1 pmol/min transferred to myelin basic protein at 30 degree C).
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of p38a/SAPK2a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for p38a/SAPK2a recombinant protein

   Description: p38/SAPK2 is a non-glycosilated polypeptide produced by phosphorylation of the purified p38 alpha with MKK6 having a molecular mass of 42.7 kDa.

Introduction: p38a/SAPK2 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
 Product Categories/Family for p38a/SAPK2a recombinant protein    PROTEIN KINASES; Enzymes; Protein Kinases
NCBI/Uniprot data below describe general gene information for p38a/SAPK2a. It may not necessarily be applicable to this product.
 NCBI GI #    4503069
 NCBI GeneID    1432
 NCBI Accession #    NP_001306.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001315.2 [Other Products]
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 UniProt Primary Accession #    Q16539 [Other Products]
 UniProt Secondary Accession #    O60776; Q13083; Q14084; Q8TDX0; A6ZJ92; A8K6P4; B0LPH0; B5TY32 [Other Products]
 UniProt Related Accession #    Q16539 [Other Products]
 Molecular Weight    29,388 Da
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 NCBI Official Full Name    mitogen-activated protein kinase 14 isoform 1
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 14
 NCBI Official Symbol    MAPK14 [Similar Products]
 NCBI Official Synonym Symbols   
RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase 14; CSAID-binding protein; Csaids binding protein; MAP kinase 14; MAP kinase Mxi2; MAP kinase p38 alpha; MAX-interacting protein 2; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug-binding protein; mitogen-activated protein kinase p38 alpha; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha Exip; stress-activated protein kinase 2A
 UniProt Protein Name    Mitogen-activated protein kinase 14
 UniProt Synonym Protein Names   
Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein 2; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Stress-activated protein kinase 2a; SAPK2a
 UniProt Gene Name    MAPK14 [Similar Products]
 UniProt Synonym Gene Names    CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; MAP kinase 14; MAPK 14; CSAID-binding protein; CSBP; MAP kinase p38 alpha; SAPK2a [Similar Products]
 UniProt Entry Name    MK14_HUMAN
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 NCBI Summary for p38a/SAPK2a    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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 UniProt Comments for p38a/SAPK2a    P38A: a proline-directed ser/thr MAP kinase, and one of four p38 kinases that play important roles in cellular responses to inflammatory cytokines, DNA damage, oxidative stress, and some GPCRs, leading to direct activation of transcription factors and of other downstream kinases including MSK1, MSK2, eEF2K, MK2, and PRAK. MSK1 and -2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli. MK2 and -3 control gene expression mostly at the post-transcriptional level. eEF2K is important for the elongation of mRNA during translation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17, which then cleaves the ectodomain of TGF-alpha family ligands, a process leading to the activation of EGFR signaling and cell proliferation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, CHOPO, p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. Interacts directly with HDAC3 interacts directly and selectively to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. May also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Regulates the endocytosis of membrane receptors that depend on RAB5A. Regulates the clathrin-mediated internalization of EGFR induced by inflammatory cytokines and UV irradiation by phosphorylating the EGFR and RAB5A effectors. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Interacts with casein kinase II subunits CSNK2A1 and CSNK2B. Activated by cell stresses such as DNA damage, heat shock, osmotic shock, anisomycin and sodium arsenite, as well as pro-inflammatory stimuli such as LPS and IL-1. Phosphorylated by ZAP70 in an alternative activation pathway in response to TCR signaling in T-cells, a pathway is inhibited by GADD45A. Four alternatively spliced isoforms of the human protein have been observed. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis

Protein type: EC 2.7.11.24; Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; MAPK family; MAPK/p38 subfamily; p38 subfamily

Chromosomal Location of Human Ortholog: 6p21.3-p21.2

Cellular Component: nucleoplasm; spindle pole; mitochondrion; cytoplasm; nucleus; cytosol

Molecular Function: MAP kinase activity; MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; NFAT protein binding; ATP binding

Biological Process: nerve growth factor receptor signaling pathway; apoptosis; activation of MAPK activity; stress-activated MAPK cascade; cell morphogenesis; toll-like receptor 3 signaling pathway; osteoclast differentiation; chemotaxis; signal transduction; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; cell surface receptor linked signal transduction; regulation of transcription factor activity; transmembrane receptor protein serine/threonine kinase signaling pathway; lipopolysaccharide-mediated signaling pathway; chondrocyte differentiation; angiogenesis; toll-like receptor 4 signaling pathway; cartilage condensation; platelet activation; mitochondrion organization and biogenesis; skeletal muscle development; transcription, DNA-dependent; positive regulation of erythrocyte differentiation; MyD88-independent toll-like receptor signaling pathway; organelle organization and biogenesis; positive regulation of blood vessel endothelial cell migration; DNA damage response, signal transduction; glucose metabolic process; positive regulation of myoblast differentiation; toll-like receptor 2 signaling pathway; regulation of transcription from RNA polymerase II promoter; MyD88-dependent toll-like receptor signaling pathway; muscle cell differentiation; peptidyl-serine phosphorylation; positive regulation of protein import into nucleus; response to muramyl dipeptide; DNA damage checkpoint; Ras protein signal transduction; toll-like receptor signaling pathway; positive regulation of muscle cell differentiation; striated muscle cell differentiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; fatty acid oxidation; gene expression; toll-like receptor 9 signaling pathway; cell motility; vascular endothelial growth factor receptor signaling pathway; blood coagulation; myoblast cell differentiation involved in skeletal muscle regeneration
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 Research Articles on p38a/SAPK2a    1. p38 MAPK was identified as a key regulator of the expression of proinflammatory gene sets, and p38 MAPK activation was found to be increased in the diabetic vs. control myotubes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with p38a/SAPK2a recombinant proteinPathways associated with p38a/SAPK2a recombinant protein
 Reference Product  PubMed Publications
 MAPKAPK2 recombinant protein  >23 publications with p38a/SAPK2a and MAPKAPK2
 MAP2K6 recombinant protein  >18 publications with p38a/SAPK2a and MAP2K6
 MAP2K3 recombinant protein  >15 publications with p38a/SAPK2a and MAP2K3
 ATF2 recombinant protein  >10 publications with p38a/SAPK2a and ATF2
 DUSP1 recombinant protein  >5 publications with p38a/SAPK2a and DUSP1
 MEF2C recombinant protein  >2 publications with p38a/SAPK2a and MEF2C
 DUSP10 recombinant protein  >2 publications with p38a/SAPK2a and DUSP10
 DUSP16 recombinant protein  >2 publications with p38a/SAPK2a and DUSP16
 MEF2A recombinant protein  >1 publications with p38a/SAPK2a and MEF2A
 Products by Pathway  Pathway Diagram
 ADP Signalling Through P2Y Purinoceptor 1 Pathway antibodies  ADP Signalling Through P2Y Purinoceptor 1 Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway antibodies  Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Diseases associated with p38a/SAPK2a recombinant proteinOrgans/Tissues associated with p38a/SAPK2a recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >79 publications with p38a/SAPK2a and Inflammation
 Necrosis Antibodies  >65 publications with p38a/SAPK2a and Necrosis
 Nervous System Diseases Antibodies  >27 publications with p38a/SAPK2a and Nervous System Diseases
 Heart Diseases Antibodies  >24 publications with p38a/SAPK2a and Heart Diseases
 Cell Transformation, Neoplastic Antibodies  >19 publications with p38a/SAPK2a and Cell Transformation, Neoplastic
 Myocardial Ischemia Antibodies  >15 publications with p38a/SAPK2a and Myocardial Ischemia
 Lung Neoplasms Antibodies  >13 publications with p38a/SAPK2a and Lung Neoplasms
 Liver Diseases Antibodies  >12 publications with p38a/SAPK2a and Liver Diseases
 Fibrosis Antibodies  >12 publications with p38a/SAPK2a and Fibrosis
 Breast Neoplasms Antibodies  >9 publications with p38a/SAPK2a and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >77 publications with p38a/SAPK2a and Blood
 Muscle Antibodies  >65 publications with p38a/SAPK2a and Muscle
 Heart Antibodies  >44 publications with p38a/SAPK2a and Heart
 Bone Antibodies  >30 publications with p38a/SAPK2a and Bone
 Lung Antibodies  >30 publications with p38a/SAPK2a and Lung
 Liver Antibodies  >29 publications with p38a/SAPK2a and Liver
 Brain Antibodies  >24 publications with p38a/SAPK2a and Brain
 Vascular Antibodies  >22 publications with p38a/SAPK2a and Vascular
 Intestine Antibodies  >14 publications with p38a/SAPK2a and Intestine
 Kidney Antibodies  >14 publications with p38a/SAPK2a and Kidney
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