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L1/HPV18 recombinant protein :: papillomavirus type 18 L1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1265161
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

papillomavirus type 18 L1 (L1/HPV18), Recombinant Protein

 Also Known As   

Recombinant Human papillomavirus type 18 L1 protein

 Product Gene Name   

L1/HPV18 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    358-533aa; Partial
 Sequence    GSIVTSDSQL FNKPYWLHKA QGHNNGVCWH NQLFVTVVDT TPSTNLTICA STQSPVPGQY DATKFKQYSR HVEEYDLQFI FQLCTITLTA DVMSYIHSMN SSILEDWNFG VPPPPTTSLV DTYRFVQSVA ITCQKDAAPA ENKDPYDKLK FWNVDLKEKF SLDLDQYPLG RKFLVQ
 3D Structure    ModBase 3D Structure for P06794
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of L1/HPV18 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for L1/HPV18 recombinant protein

   Forms an icosahedral capsid with a T=7 symmetry and about 55 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. The capsid encapsulates the genomic DNA, but does not bind DNA. Essential for the initial attachment to the host cell.
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 SDS-PAGE of L1/HPV18 recombinant protein    L1/HPV18 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for L1/HPV18. It may not necessarily be applicable to this product.
 NCBI GI #    9626077
 NCBI GeneID    1489090
 NCBI Accession #    NP_040317.1 [Other Products]
 NCBI GenBank Nucleotide #    NC_001357.1 [Other Products]
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 UniProt Primary Accession #    P06794 [Other Products]
 UniProt Secondary Accession #    Q84270 [Other Products]
 UniProt Related Accession #    CAA28671 [Other Products]
 Molecular Weight    24.2kD
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 NCBI Official Full Name    L1 protein
 NCBI Official Symbol    L1 [Similar Products]
 NCBI Protein Information    major capsid L1 protein
 UniProt Protein Name    Major capsid protein L1
 UniProt Gene Name    L1 [Similar Products]
 UniProt Entry Name    VL1_HPV18
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 UniProt Comments for L1/HPV18    Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.
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Product References and Citations for L1/HPV18 recombinant protein

   Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products.Cole S.T., Danos O.J. Mol. Biol. 193:599-608(1987) Phylogenetic analysis of 48 papillomavirus types and 28 subtypes and variants a showcase for the molecular evolution of DNA viruses.Chan S.-Y., Bernard H.U., Ong C.K., Chan S.P., Birgit H., Delius H.J. Virol. 66:5714-5725(1992) Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens.Thierry F., Heard J.-M., Dartmann K., Yaniv M.J. Virol. 61:134-142(1987)
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 Research Articles on L1/HPV18    1. L1 sequences were strongly methylated in all cervical carcinomas studied; hypothesize that L1 is preferentially methylated after integration of the HPV genome into the cellular DNA
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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