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PRL recombinant protein :: prolactin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS400060 PRL recombinant protein
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $215 +1 FREE 8GB USB
0.1 mg  /  $295 +1 FREE 8GB USB
0.5 mg  /  $740 +1 FREE 8GB USB
1 mg  /  $1,230 +1 FREE 8GB USB
5 mg  /  $3,980 +4 FREE 8GB USB
10 mg  /  $7,085 +8 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

prolactin (PRL), Recombinant Protein

 Also Known As   

Human prolactin

 Product Synonym Names    Human prolactin (hPRL)
 Product Gene Name   

PRL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first six N-terminal amino acids was determined and was found to be Ala-Leu-Pr o-Ile-Cys- Pro
 OMIM    176760
 3D Structure    ModBase 3D Structure for P01236
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 Host    E Coli
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 Purity/Purification    Greater than 99.0% as determined by:
(a) Gel filtration analysis.
(b) Analysis by reducing and non-reducing SDS-PAGE gel.
 Form/Format    White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized hPRL in sterile water or 0.4% NaHCO3 adjusted tp pH 8-9, not less than 100ug/ml, which can then be further diluted to other aqueous solutions, preferably in presence of carrier protein.
 Protein Content    Protein content:Protein quantitation was carried out by UV spectroscopy at 280 nm using the absorbency value of 0.85 as the extinction coefficient for a 0.1% (1mg/ml) solution at pH 8.0. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics).
 Dimers and Aggregates    The purified hPRL (23K) consists of > 99% monomers as determined by gel-filtration chromatography.
 Endotoxin    Less than 0.1 ng/ug (IEU/ug) of hPRL
 Formulation    The protein was lyophilized from a concentrated (1mg/ml) solution with 0.02-0.03% NaHCO3.
 Biological Activity    hPRL is fully biologically active as evidenced by inducing proliferation of Nb2 cells.
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 Preparation and Storage    Lyophilized hPRL although stable at room temperature for several weeks, should be stored desiccated below -18 degree C. Upon reconstitution at > 0.1 hPRL mg/ml and up to 4 mg/ml and filter sterilization hPRL can be stored at 4 degree C for several weeks.
 Other Notes    Small volumes of PRL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PRL recombinant protein

   Recombinant human prolactin, one polypeptide chain containing 199 amino and an additional Ala at N-terminus acids and having a molecular mass of ~ 23 kDa, was purified by proprietary chromatographic techniques.
 Product Categories/Family for PRL recombinant protein    Growth hormones, prolactins, placental lactogens
NCBI/Uniprot data below describe general gene information for PRL. It may not necessarily be applicable to this product.
 NCBI GI #    4506105
 NCBI GeneID    5617
 NCBI Accession #    NP_000939.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000948.5 [Other Products]
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 UniProt Primary Accession #    P01236 [Other Products]
 UniProt Secondary Accession #    Q15199; Q92996 [Other Products]
 UniProt Related Accession #    P01236 [Other Products]
 Molecular Weight    25,876 Da [Similar Products]
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 NCBI Official Full Name    prolactin
 NCBI Official Synonym Full Names    prolactin
 NCBI Official Symbol    PRL [Similar Products]
 NCBI Protein Information    prolactin; decidual prolactin
 UniProt Protein Name    Prolactin
 Protein Family    Prolactin
 UniProt Gene Name    PRL [Similar Products]
 UniProt Synonym Gene Names    PRL [Similar Products]
 UniProt Entry Name    PRL_HUMAN
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 NCBI Summary for PRL    This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
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 UniProt Comments for PRL    prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family.

Protein type: Secreted, signal peptide; Cytokine; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: extracellular region

Molecular Function: protein binding; prolactin receptor binding; hormone activity

Biological Process: lactation; cell proliferation; cell surface receptor linked signal transduction; regulation of multicellular organism growth; positive regulation of JAK-STAT cascade; female pregnancy
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 Research Articles on PRL    1. The prevalence and predictors of hyperprolactinemia in 178 patients with liver cirrhosis of different etio-logies, were investigated.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRL recombinant proteinPathways associated with PRL recombinant protein
 Reference Product  PubMed Publications
 TRH recombinant protein  >1759 publications with PRL and TRH
 PRLR recombinant protein  >357 publications with PRL and PRLR
 JAK2 recombinant protein  >190 publications with PRL and JAK2
 POU1F1 recombinant protein  >141 publications with PRL and POU1F1
 STAT5A recombinant protein  >80 publications with PRL and STAT5A
 STAT3 recombinant protein  >63 publications with PRL and STAT3
 GHR recombinant protein  >52 publications with PRL and GHR
 STAT5B recombinant protein  >47 publications with PRL and STAT5B
 ESR1 recombinant protein  >12 publications with PRL and ESR1
 BMP1 recombinant protein  >2 publications with PRL and BMP1
 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Growth Hormone Receptor Signaling Pathway antibodies  Growth Hormone Receptor Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with PRL recombinant proteinOrgans/Tissues associated with PRL recombinant protein
 Disease Name  Pubmed Publications
 Pituitary Neoplasms Antibodies  >2037 publications with PRL and Pituitary Neoplasms
 Hyperprolactinemia Antibodies  >1529 publications with PRL and Hyperprolactinemia
 Adenoma Antibodies  >1499 publications with PRL and Adenoma
 Prolactinoma Antibodies  >685 publications with PRL and Prolactinoma
 Mental Disorders Antibodies  >608 publications with PRL and Mental Disorders
 Amenorrhea Antibodies  >428 publications with PRL and Amenorrhea
 Galactorrhea Antibodies  >318 publications with PRL and Galactorrhea
 Growth Hormone-Secreting Pituitary Adenoma Antibodies  >266 publications with PRL and Growth Hormone-Secreting Pituitary Adenoma
 Infertility, Female Antibodies  >240 publications with PRL and Infertility, Female
 Hypogonadism Antibodies  >209 publications with PRL and Hypogonadism
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5144 publications with PRL and Brain
 Pituitary Gland Antibodies  >3994 publications with PRL and Pituitary Gland
 Uterus Antibodies  >522 publications with PRL and Uterus
 Testis Antibodies  >498 publications with PRL and Testis
 Placenta Antibodies  >391 publications with PRL and Placenta
 Heart Antibodies  >209 publications with PRL and Heart
 Eye Antibodies  >195 publications with PRL and Eye
 Muscle Antibodies  >192 publications with PRL and Muscle
 Connective Tissue Antibodies  >121 publications with PRL and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with PRL and Uncharacterized Tissue
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