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sFRP1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS539401 sFRP1 recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

sFRP1, Recombinant Protein

 Also Known As   

sFRP1 protein

 Product Synonym Names    SFRP-1 protein; Secreted Frizzled Related Protein 1 protein; sFRP-1 protein; sFRP 1; sFRP 1 protein; Secreted Apoptosis Related Protein-2 protein; sFRP-1; sFRP1; Soluble Frizzled Related Protein-1 protein; SARP-2 protein
 Product Gene Name   

sFRP1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK
 OMIM    604156
 3D Structure    ModBase 3D Structure for Q8N474
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 Purity/Purification    > or = 97% by SDS-PAGE and HPLC
 Concentration    20ug lyophilized (lot specific)
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 Source    HeLa cells
 Species    Human
 Protein Type    Recombinant
 Biological Significance    Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas.
 Bioactivity    Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3-0.5 ug/ml.
 Endotoxin Levels    < 0.1 ng/ug (1 EU/ug).
 Contaminants    Endotoxin: <0.1ng/ug(<1EU/ug)
 Form    Lyophilized powder. Centrifuge the vial prior to opening. Reconstitute with water to a concentration of 0.1-1mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containg a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.
 Biohazard    Use appropriate laboratory precautions when handling this product.
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 Preparation and Storage    Ships ambient or refrigerated; after receipt, store at 4 degree C short term, -20 degree C long term
 Other Notes    Small volumes of sFRP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for sFRP1 recombinant protein

   Purified recombinant Human sFRP1 protein
 Product Categories/Family for sFRP1 recombinant protein    Cancer
 Applications Tested/Suitable for sFRP1 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for sFRP1. It may not necessarily be applicable to this product.
 NCBI GI #    22209051
 NCBI GeneID    6422
 NCBI Accession #    AAH36503.1 [Other Products]
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 UniProt Primary Accession #    Q8N474 [Other Products]
 UniProt Secondary Accession #    O00546; O14779 [Other Products]
 UniProt Related Accession #    Q8N474 [Other Products]
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 NCBI Official Full Name    Secreted frizzled-related protein 1
 NCBI Official Synonym Full Names    secreted frizzled-related protein 1
 NCBI Official Symbol    SFRP1 [Similar Products]
 NCBI Official Synonym Symbols   
FRP; FRP1; FrzA; FRP-1; SARP2
[Similar Products]
 NCBI Protein Information    secreted frizzled-related protein 1
 UniProt Protein Name    Secreted frizzled-related protein 1
 UniProt Synonym Protein Names   
Secreted apoptosis-related protein 2; SARP-2
 Protein Family    Secreted frizzled-related protein
 UniProt Gene Name    SFRP1 [Similar Products]
 UniProt Synonym Gene Names    FRP; FRP1; SARP2; FRP-1; sFRP-1; SARP-2 [Similar Products]
 UniProt Entry Name    SFRP1_HUMAN
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 NCBI Summary for sFRP1    This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
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 UniProt Comments for sFRP1    SFRP1: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription. Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4 and WNT8. Down-regulated in colorectal and breast tumors. Up- regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions. Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8p11.21

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; cell surface; extracellular region; plasma membrane; integral to membrane; intracellular; cytosol

Molecular Function: heparin binding; G-protein coupled receptor activity; Wnt-protein binding; identical protein binding; protein binding; Wnt receptor activity; frizzled binding; cysteine-type endopeptidase activity; drug binding

Biological Process: negative regulation of osteoclast differentiation; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; dorsal/ventral axis specification; Wnt receptor signaling pathway through beta-catenin; proteolysis; response to organic cyclic substance; negative regulation of BMP signaling pathway; negative regulation of insulin secretion; negative regulation of cell proliferation; positive regulation of focal adhesion formation; ureteric bud development; positive regulation of stress fiber formation; positive regulation of cell proliferation; negative regulation of ossification; positive regulation of smoothened signaling pathway; negative regulation of osteoblast differentiation; positive regulation of cell-matrix adhesion; positive regulation of Wnt receptor signaling pathway; negative regulation of cell migration; female gonad development; negative regulation of epithelial cell proliferation; response to drug; negative regulation of B cell differentiation; negative regulation of JNK activity; negative regulation of peptidyl-tyrosine phosphorylation; menstrual cycle phase; male gonad development; digestive tract morphogenesis; cellular response to starvation; positive regulation of cell growth; regulation of angiogenesis; osteoblast differentiation; negative regulation of fibroblast proliferation; negative regulation of bone remodeling; neural tube closure; positive regulation of fat cell differentiation; neural crest cell fate commitment; hemopoietic progenitor cell differentiation; negative regulation of osteoblast proliferation; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; positive regulation of epithelial cell proliferation; negative regulation of apoptosis
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 Research Articles on sFRP1    1. Sfrp1 contributes to coordination of visual axon growth in retinal ganglion cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with sFRP1 recombinant proteinPathways associated with sFRP1 recombinant protein
 Reference Product  PubMed Publications
 WNT3A recombinant protein  >30 publications with sFRP1 and WNT3A
 WNT5A recombinant protein  >29 publications with sFRP1 and WNT5A
 WNT10B recombinant protein  >16 publications with sFRP1 and WNT10B
 WNT1 recombinant protein  >16 publications with sFRP1 and WNT1
 WNT4 recombinant protein  >14 publications with sFRP1 and WNT4
 WNT7B recombinant protein  >9 publications with sFRP1 and WNT7B
 WNT2 recombinant protein  >9 publications with sFRP1 and WNT2
 WNT8A recombinant protein  >5 publications with sFRP1 and WNT8A
 WNT7A recombinant protein  >4 publications with sFRP1 and WNT7A
 WNT8B recombinant protein  >4 publications with sFRP1 and WNT8B
 Products by Pathway  Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram
 TCF Dependent Signaling In Response To WNT Pathway antibodies  TCF Dependent Signaling In Response To WNT Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway antibodies  Negative Regulation Of TCF-dependent Signaling By WNT Ligand Antagonists Pathway Diagram
Diseases associated with sFRP1 recombinant proteinOrgans/Tissues associated with sFRP1 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >131 publications with sFRP1 and Carcinoma
 Colorectal Neoplasms Antibodies  >54 publications with sFRP1 and Colorectal Neoplasms
 Breast Neoplasms Antibodies  >49 publications with sFRP1 and Breast Neoplasms
 Liver Neoplasms Antibodies  >23 publications with sFRP1 and Liver Neoplasms
 Liver Diseases Antibodies  >23 publications with sFRP1 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >22 publications with sFRP1 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >22 publications with sFRP1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >20 publications with sFRP1 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >20 publications with sFRP1 and Kidney Diseases
 Lung Diseases Antibodies  >19 publications with sFRP1 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >79 publications with sFRP1 and Bone
 Eye Antibodies  >72 publications with sFRP1 and Eye
 Brain Antibodies  >39 publications with sFRP1 and Brain
 Liver Antibodies  >37 publications with sFRP1 and Liver
 Lung Antibodies  >35 publications with sFRP1 and Lung
 Embryonic Tissue Antibodies  >35 publications with sFRP1 and Embryonic Tissue
 Muscle Antibodies  >27 publications with sFRP1 and Muscle
 Kidney Antibodies  >26 publications with sFRP1 and Kidney
 Connective Tissue Antibodies  >26 publications with sFRP1 and Connective Tissue
 Intestine Antibodies  >22 publications with sFRP1 and Intestine
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