NP_011937.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,514 Da
NCBI Official Full Name
tRNA (guanine) methyltransferase
NCBI Protein Information
tRNA (guanine) methyltransferase
UniProt Protein Name
tRNA (guanine(37)-N1)-methyltransferase
UniProt Synonym Protein Names
M1G-methyltransferase
UniProt Comments for TRM5
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Postspliced cytoplasmic tRNAs are imported into the nucleus, where this first step seems to take place, after which they are reexported to the cytoplasm, where the yW sythesis is completed by cytoplasmic enzymes.
Research Articles on TRM5
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Products associated with TRM5 recombinant protein
Pathways associated with TRM5 recombinant protein
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