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uROD recombinant protein

Scan QR to view Datasheet Catalog #    MBS203449
SDS-PAGE
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
0.5 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

uROD, Recombinant Protein

 Also Known As   

uROD, 1-367aa, Human, His tag, E Coli

 Product Synonym Names    PCT; uroporphyrinogen decarboxylase; uPD; uRO D; uRO-D
 Product Gene Name   

uROD recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MEANGLGPQG FPELKNDTFL RAAWGEETDY TPVWCMRQAG RYLPEFRETR AAQDFFSTCR SPEACCELTL QPLRRFPLDA AIIFSDILVV PQALGMEVTM VPGKGPSFPE PLREEQDLER LRDPEVVASE LGYVFQAITL TRQRLAGRVP LIGFAGAPWT LMTYMVEGGG SSTMAQAKRW LYQRPQASHQ LLRILTDALV PYLVGQVVAG AQALQLFESH AGHLGPQLFN KFALPYIRDV AKQVKARLRE AGLAPVPMII FAKDGHFALE ELAQAGYEVV GLDWTVAPKK ARECVGKTVT LQVNLDPCAL YASEEEIGQL VKQMLDDFGP HRYIANLGHG LYPDMDPEHV GAFVDAVHKH SRLLRQN
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 Purity/Purification    > 95 % by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol 1mM DTT, 0.1M NaCl, and 1mM EDTA.
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of uROD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for uROD recombinant protein

   uROD is the fifth enzyme in the human heme biosynthetic pathway and is responsible for the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are responsible for three autosomal disorders in humans: familial porphyria cutanea tarda (f-PCT), sporadic porphyria cutanea tarda (s-PCT) and hepatoerythropoietic porphyria (HEP). Recombinant human uROD protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for uROD recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for uROD recombinant protein   

SDS-PAGE

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 SDS-PAGE of uROD recombinant protein    uROD recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for uROD. It may not necessarily be applicable to this product.
 NCBI GI #    12804699
 NCBI GeneID    7389
 NCBI Accession #    AAH01778 [Other Products]
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 UniProt Secondary Accession #    Q16863; Q16883; Q53YB8; Q53ZP6; Q6IB28; Q9BUZ0; A8K762 [Other Products]
 UniProt Related Accession #    P06132 [Other Products]
 Molecular Weight    43.0 kDa (387aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    Uroporphyrinogen decarboxylase
 NCBI Official Synonym Full Names    uroporphyrinogen decarboxylase
 NCBI Official Symbol    UROD [Similar Products]
 NCBI Official Synonym Symbols   
PCT; UPD
[Similar Products]
 NCBI Protein Information    uroporphyrinogen decarboxylase; uroporphyrinogen III decarboxylase
 UniProt Protein Name    Uroporphyrinogen decarboxylase
 UniProt Gene Name    UROD [Similar Products]
 UniProt Synonym Gene Names    UPD; URO-D [Similar Products]
 UniProt Entry Name    DCUP_HUMAN
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 NCBI Summary for uROD    This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]
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 UniProt Comments for uROD    UROD: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. Defects in UROD are the cause of familial porphyria cutanea tarda (FPCT); also known as porphyria cutanea tarda type II. FPCT is an autosomal dominant disorder characterized by light-sensitive dermatitis, with onset in later life. It is associated with the excretion of large amounts of uroporphyrin in the urine. Iron overload is often present in association with varying degrees of liver damage. Besides the familial form of PCT, a relatively common idiosyncratic form is known in which only the liver enzyme is reduced. This form is referred to as porphyria cutanea tarda sporadic type or type I. PCT type I occurs sporadically as an unusual accompaniment of common hepatic disorders such as alcohol- associated liver disease. Defects in UROD are the cause of hepatoerythropoietic porphyria (HEP). HEP is a rare autosomal recessive disorder. It is the severe form of cutaneous porphyria, and presents in infancy. The level of UROD is very low in erythrocytes and cultured skin fibroblasts, suggesting that HEP is the homozygous state for porphyria cutanea tarda. Belongs to the uroporphyrinogen decarboxylase family.

Protein type: EC 4.1.1.37; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Lyase

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: nucleoplasm; cytoplasm; cytosol

Molecular Function: uroporphyrinogen decarboxylase activity

Biological Process: porphyrin metabolic process; protoporphyrinogen IX biosynthetic process; heme biosynthetic process

Disease: Porphyria Cutanea Tarda
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Product References and Citations for uROD recombinant protein

   Lewis CA Jr., et al. (2008) Proc Natl Acad Sci u S A. 105(45):17328-33.
Garey JR., et al. (1989) Blood. 73(4):892-5.
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 Research Articles on uROD    1. Data suggest that the traditional Chinese medicine (TCM) candidate potential three-in-one inhibitors for three drug target proteins epidermal growth factor receptor (EGFR), Her2, and uroporphyrinogen decarboxylase (UROD) against head and neck cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with uROD recombinant proteinPathways associated with uROD recombinant protein
 Reference Product  PubMed Publications
 HFE recombinant protein  >14 publications with uROD and HFE
 CPOX recombinant protein  >5 publications with uROD and CPOX
 PPOX recombinant protein  >2 publications with uROD and PPOX
 ALAD recombinant protein  >2 publications with uROD and ALAD
 HMBS recombinant protein  >2 publications with uROD and HMBS
 UROS recombinant protein  >2 publications with uROD and UROS
 FECH recombinant protein  >1 publications with uROD and FECH
 Products by Pathway  Pathway Diagram
 Heme Biosynthesis Pathway antibodies  Heme Biosynthesis Pathway Diagram
 Heme Biosynthesis Pathway antibodies  Heme Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Porphyrins Pathway antibodies  Metabolism Of Porphyrins Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
Diseases associated with uROD recombinant proteinOrgans/Tissues associated with uROD recombinant protein
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >67 publications with uROD and Skin Diseases
 Porphyria Cutanea Tarda Antibodies  >66 publications with uROD and Porphyria Cutanea Tarda
 Liver Diseases Antibodies  >57 publications with uROD and Liver Diseases
 Poisoning Antibodies  >5 publications with uROD and Poisoning
 Drug-Induced Liver Injury Antibodies  >4 publications with uROD and Drug-Induced Liver Injury
 Pain Antibodies  >3 publications with uROD and Pain
 Carcinoma, Hepatocellular Antibodies  >2 publications with uROD and Carcinoma, Hepatocellular
 Drug-Related Side Effects and Adverse Reactions Antibodies  >2 publications with uROD and Drug-Related Side Effects and Adverse Reactions
 Anemia Antibodies  >2 publications with uROD and Anemia
 Necrosis Antibodies  >2 publications with uROD and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >37 publications with uROD and Liver
 Blood Antibodies  >28 publications with uROD and Blood
 Skin Antibodies  >21 publications with uROD and Skin
 Kidney Antibodies  >4 publications with uROD and Kidney
 Heart Antibodies  >2 publications with uROD and Heart
 Brain Antibodies  >2 publications with uROD and Brain
 Pancreas Antibodies  >1 publications with uROD and Pancreas
 Spleen Antibodies  >1 publications with uROD and Spleen
 Intestine Antibodies  >1 publications with uROD and Intestine
 Embryonic Tissue Antibodies  >1 publications with uROD and Embryonic Tissue
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