P40259
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
CD79b
NCBI Official Synonym Full Names
CD79b molecule, immunoglobulin-associated beta
NCBI Protein Information
B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta)
UniProt Protein Name
B-cell antigen receptor complex-associated protein beta chain
UniProt Synonym Protein Names
B-cell-specific glycoprotein B29; Ig-beta; Immunoglobulin-associated B29 protein
UniProt Synonym Gene Names
UniProt Entry Name
CD79B_HUMAN
NCBI Summary for CD79B
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
UniProt Comments for CD79B
Function: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Ref.10 Ref.11 Ref.12
Subunit structure: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Ref.14
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note: Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts
Tissue specificity: B-cells.
Post-translational modification: Phosphorylated on tyrosine upon B-cell activation.
Involvement in disease: Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [
MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Ref.15
Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.Contains 1 ITAM domain.
Product References and Citations for anti-CD79B antibody
1. Koyama, M., K. Ishihara, H. Karasuyama, J.L. Cordell, A. Iwamoto, and T. Nakamura. 1997. Int. Immunol. 9:1767. 2. Nakamura, T. Personal communication.
Research Articles on CD79B
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Products associated with anti-CD79B antibody
Pathways associated with anti-CD79B antibody
Diseases associated with anti-CD79B antibody
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>311 publications with CD79B and Neoplasms |
Immune System Diseases Antibodies |
>301 publications with CD79B and Immune System Diseases |
Lymphoma Antibodies |
>213 publications with CD79B and Lymphoma |
Lymphoma, B-Cell Antibodies |
>184 publications with CD79B and Lymphoma, B-Cell |
Leukemia Antibodies |
>156 publications with CD79B and Leukemia |
Lymphoma, Non-Hodgkin Antibodies |
>139 publications with CD79B and Lymphoma, Non-Hodgkin |
Leukemia, Lymphocytic, Chronic, B-Cell Antibodies |
>80 publications with CD79B and Leukemia, Lymphocytic, Chronic, B-Cell |
Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies |
>27 publications with CD79B and Precursor Cell Lymphoblastic Leukemia-Lymphoma |
Hodgkin Disease Antibodies |
>27 publications with CD79B and Hodgkin Disease |
Skin Neoplasms Antibodies |
>22 publications with CD79B and Skin Neoplasms |
Organs/Tissues associated with anti-CD79B antibody
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