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PCK2 substrate :: Phosphoenolpyruvate Substrate

Scan QR to view Datasheet Catalog #    MBS653912
Test Data
Unit / Price
1 g  /  $525 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phosphoenolpyruvate (PCK2), Substrate

★Popular Item★
 Also Known As   

Phosphoenolpyruvate (PEP)

 Product Gene Name   

PCK2 substrate

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (24563347..24573339). Location: 14q11.2
 OMIM    261650
 3D Structure    ModBase 3D Structure for Q16822
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 Purity/Purification    Highly Purified
98.6%
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 Molecular Formula    C3H4O6P• C6H14N
 Water    0.1%
 Pyruvate content    0.005%
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of PCK2 substrate vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for PCK2 substrate    Molecular Biology
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 Test Data of PCK2 substrate    PCK2 substrate Test Data image
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NCBI/Uniprot data below describe general gene information for PCK2. It may not necessarily be applicable to this product.
 NCBI GI #    66346721
 NCBI GeneID    5106
 NCBI Accession #    NP_004554.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004563.2 [Other Products]
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 UniProt Primary Accession #    Q16822 [Other Products]
 UniProt Secondary Accession #    O43253; Q86U01; Q9BV62 [Other Products]
 UniProt Related Accession #    Q16822 [Other Products]
 Molecular Weight    267.22 anhy [Similar Products]
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 NCBI Official Full Name    phosphoenolpyruvate carboxykinase
 NCBI Official Synonym Full Names    phosphoenolpyruvate carboxykinase 2 (mitochondrial)
 NCBI Official Symbol    PCK2 [Similar Products]
 NCBI Official Synonym Symbols   
PEPCK; PEPCK2; PEPCK-M
[Similar Products]
 NCBI Protein Information    phosphoenolpyruvate carboxykinase [GTP], mitochondrial; phosphoenolpyruvate carboxykinase [GTP], mitochondrial; PEP carboxykinase; phosphopyruvate carboxylase; phosphoenolpyruvate carboxylase
 UniProt Protein Name    Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
 UniProt Synonym Protein Names   
Phosphoenolpyruvate carboxylase
 Protein Family    Protein kinase
 UniProt Gene Name    PCK2 [Similar Products]
 UniProt Synonym Gene Names    PEPCK2; PEPCK-M [Similar Products]
 UniProt Entry Name    PCKGM_HUMAN
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 NCBI Summary for PCK2    This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PCK2    Function: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle

By similarity.

Catalytic activity: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.

Cofactor: Manganese

By similarity.Binds 1 manganese ion per subunit

By similarity.

Pathway: Carbohydrate biosynthesis; gluconeogenesis.

Subunit structure: Monomer.

Subcellular location: Mitochondrion.

Involvement in disease: Mitochondrial phosphoenolpyruvate carboxykinase deficiency (M-PEPCKD) [MIM:261650]: Metabolic disorder resulting from impaired gluconeogenesis. It is a rare disease with less than 10 cases reported in the literature. Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia. Autopsy reveals fatty infiltration of both the liver and kidneys. The disorder is transmitted as an autosomal recessive trait.Note: The disease is caused by mutations affecting the gene represented in this entry.

Miscellaneous: In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one.

Sequence similarities: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Sequence caution: The sequence CAD62600.1 differs from that shown. Reason: Erroneous initiation.
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 Research Articles on PCK2    1. expression of HCV nonstructural component NS5A in Huh7 or primary hepatocytes stimulated PEPCK gene expression and glucose output in HepG2 cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PCK2 substratePathways associated with PCK2 substrate
 Reference Product  PubMed Publications
 INS substrate  >1 publications with PCK2 and INS
 AKT1 substrate  >1 publications with PCK2 and AKT1
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
Diseases associated with PCK2 substrateOrgans/Tissues associated with PCK2 substrate
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >5 publications with PCK2 and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >3 publications with PCK2 and Carcinoma, Hepatocellular
 Neoplasms Antibodies  >3 publications with PCK2 and Neoplasms
 Liver Diseases Antibodies  >2 publications with PCK2 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with PCK2 and Liver Neoplasms
 Adenocarcinoma Antibodies  >2 publications with PCK2 and Adenocarcinoma
 Disease Models, Animal Antibodies  >1 publications with PCK2 and Disease Models, Animal
 Weight Loss Antibodies  >1 publications with PCK2 and Weight Loss
 Hepatitis Antibodies  >1 publications with PCK2 and Hepatitis
 Inflammation Antibodies  >1 publications with PCK2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >13 publications with PCK2 and Liver
 Blood Antibodies  >10 publications with PCK2 and Blood
 Adipose Tissue Antibodies  >9 publications with PCK2 and Adipose Tissue
 Connective Tissue Antibodies  >5 publications with PCK2 and Connective Tissue
 Kidney Antibodies  >4 publications with PCK2 and Kidney
 Embryonic Tissue Antibodies  >3 publications with PCK2 and Embryonic Tissue
 Pancreas Antibodies  >3 publications with PCK2 and Pancreas
 Muscle Antibodies  >2 publications with PCK2 and Muscle
 Heart Antibodies  >2 publications with PCK2 and Heart
 Placenta Antibodies  >1 publications with PCK2 and Placenta
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