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HMGB-1 western blot control :: High Mobility Group Protein B1 (HMGB-1) Western Blot Control

Scan QR to view Datasheet Catalog #    MBS343250 HMGB-1 western blot control
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

High Mobility Group Protein B1 (HMGB-1), Western Blot Control

 Also Known As   

High Mobility Group Protein B1 (HMGB-1) (Western Blot Control)

 Product Gene Name   

HMGB-1 western blot control

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    163905
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 Purity/Purification    >= 95% (SDS PAGE)
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 Buffer    Buffered 50% glycerol
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 ISO Certification    Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
 Other Notes    Small volumes of HMGB-1 western blot control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for HMGB-1 western blot control

   High Mobility Group Protein B1 (HMGB-1) (Western Blot Control)
 Product Categories/Family for HMGB-1 western blot control    Recombinant Proteins; High Mobility Group Protein B1 (HMGB-1)
NCBI/Uniprot data below describe general gene information for HMGB-1. It may not necessarily be applicable to this product.
 NCBI GI #    926459557
 NCBI GeneID    3146
 NCBI Accession #    NP_001300822.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001313893.1 [Other Products]
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 UniProt Secondary Accession #    Q14321; Q5T7C3; Q6IBE1; A5D8W9 [Other Products]
 UniProt Related Accession #    P09429 [Other Products]
 Molecular Weight    24,894 Da
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 NCBI Official Full Name    high mobility group protein B1
 NCBI Official Synonym Full Names    high mobility group box 1
 NCBI Official Symbol    HMGB1 [Similar Products]
 NCBI Official Synonym Symbols   
HMG1; HMG3; HMG-1; SBP-1
[Similar Products]
 NCBI Protein Information    high mobility group protein B1
 UniProt Protein Name    High mobility group protein B1
 UniProt Synonym Protein Names   
High mobility group protein 1; HMG-1
 UniProt Gene Name    HMGB1 [Similar Products]
 UniProt Synonym Gene Names    HMG1; HMG-1 [Similar Products]
 UniProt Entry Name    HMGB1_HUMAN
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 NCBI Summary for HMGB-1    This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
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 UniProt Comments for HMGB-1    HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family.

Protein type: DNA repair, damage; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: cell surface; condensed chromosome; extracellular region; extracellular space; nucleoplasm; nucleus; transcriptional repressor complex

Molecular Function: bubble DNA binding; C-X-C chemokine binding; chemoattractant activity; cytokine activity; damaged DNA binding; DNA bending activity; double-stranded DNA binding; four-way junction DNA binding; lipopolysaccharide binding; lyase activity; phosphatidylserine binding; protein binding; RAGE receptor binding; single-stranded DNA binding; transcription factor activity; transcription factor binding

Biological Process: activation of innate immune response; apoptotic cell clearance; dendritic cell chemotaxis; DNA fragmentation during apoptosis; DNA geometric change; DNA ligation during DNA repair; DNA recombination; DNA topological change; elevation of cytosolic calcium ion concentration; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; myeloid dendritic cell activation; negative regulation of blood vessel endothelial cell migration; negative regulation of CD4-positive, alpha beta T cell differentiation; negative regulation of interferon-gamma production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcriptional preinitiation complex assembly; neurite development; positive regulation of activated T cell proliferation; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of DNA binding; positive regulation of DNA ligation; positive regulation of interleukin-1 secretion; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; positive regulation of mismatch repair; positive regulation of toll-like receptor 9 signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of autophagy; regulation of restriction endodeoxyribonuclease activity; regulation of T cell mediated immune response to tumor cell; regulation of tolerance induction; regulation of transcription from RNA polymerase II promoter; T-helper 1 cell differentiation; V(D)J recombination
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 Research Articles on HMGB-1    1. Our data suggested that MIF affected the intrinsic properties of tumors and the host immune response in tumor microenvironment by regulating the TLR4/HMGB1 axis, leading to metastasis of breast cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HMGB-1 western blot controlPathways associated with HMGB-1 western blot control
 Reference Product  PubMed Publications
 TLR4 western blot control  >543 publications with HMGB-1 and TLR4
 TLR2 western blot control  >203 publications with HMGB-1 and TLR2
 AGER western blot control  >43 publications with HMGB-1 and AGER
 RELA western blot control  >39 publications with HMGB-1 and RELA
 TBP western blot control  >13 publications with HMGB-1 and TBP
 TP53 western blot control  >12 publications with HMGB-1 and TP53
 NFKB1 western blot control  >5 publications with HMGB-1 and NFKB1
 CREBBP western blot control  >3 publications with HMGB-1 and CREBBP
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Induced DNA Fragmentation Pathway antibodies  Apoptosis Induced DNA Fragmentation Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
Diseases associated with HMGB-1 western blot controlOrgans/Tissues associated with HMGB-1 western blot control
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1757 publications with HMGB-1 and Inflammation
 Necrosis Antibodies  >929 publications with HMGB-1 and Necrosis
 Sepsis Antibodies  >587 publications with HMGB-1 and Sepsis
 Disease Models, Animal Antibodies  >521 publications with HMGB-1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >326 publications with HMGB-1 and Nervous System Diseases
 Liver Diseases Antibodies  >243 publications with HMGB-1 and Liver Diseases
 Heart Diseases Antibodies  >171 publications with HMGB-1 and Heart Diseases
 Myocardial Ischemia Antibodies  >135 publications with HMGB-1 and Myocardial Ischemia
 Kidney Diseases Antibodies  >118 publications with HMGB-1 and Kidney Diseases
 Fibrosis Antibodies  >110 publications with HMGB-1 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1438 publications with HMGB-1 and Blood
 Liver Antibodies  >525 publications with HMGB-1 and Liver
 Lung Antibodies  >494 publications with HMGB-1 and Lung
 Brain Antibodies  >406 publications with HMGB-1 and Brain
 Vascular Antibodies  >394 publications with HMGB-1 and Vascular
 Heart Antibodies  >232 publications with HMGB-1 and Heart
 Muscle Antibodies  >232 publications with HMGB-1 and Muscle
 Kidney Antibodies  >208 publications with HMGB-1 and Kidney
 Bone Antibodies  >166 publications with HMGB-1 and Bone
 Intestine Antibodies  >122 publications with HMGB-1 and Intestine
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