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IL-8 western blot control :: Interleukin-8 (IL-8) Western Blot Control

Scan QR to view Datasheet Catalog #    MBS343082 IL-8 western blot control
Unit / Price
0.01 mg  /  $220 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-8 (IL-8), Western Blot Control

 Also Known As   

Interleukin-8 (IL-8) (Western Blot Control)

 Product Synonym Names    IL-8, CXCL8, Monocyte-derived neutrophil chemotactic factor, MDNCF, T-cell chemotactic factor, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, Granulocyte chemotactic protein 1, GCP-1, Monocyte derived neutrophil activating peptide, MONAP, Emoctakin.
 Product Gene Name   

IL-8 western blot control

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146930
 3D Structure    ModBase 3D Structure for P10145
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 Purity/Purification    >= 95% (SDS PAGE)
 Form/Format    Liquid
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 Buffer    Buffered 50% glycerol
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 ISO Certification    Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
 Other Notes    Small volumes of IL-8 western blot control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IL-8 western blot control

   Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states. Recombinant IL-8 comprises the 77 amino acid fragment (23-99) corresponding to the mature IL-8 protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.
 Product Categories/Family for IL-8 western blot control    Recombinant Proteins; Interleukin-8
NCBI/Uniprot data below describe general gene information for IL-8. It may not necessarily be applicable to this product.
 NCBI GI #    10834978
 NCBI GeneID    3576
 NCBI Accession #    NP_000575.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000584.3 [Other Products]
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 UniProt Primary Accession #    P10145 [Other Products]
 UniProt Secondary Accession #    Q6FGF6; Q6LAE6; Q96RG6; Q9C077; Q9UCE1; Q9UCR8; Q9UCR9; Q9UCS0; B2R4L8 [Other Products]
 UniProt Related Accession #    P10145 [Other Products]
 Molecular Weight    11,098 Da
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 NCBI Official Full Name    interleukin-8
 NCBI Official Synonym Full Names    C-X-C motif chemokine ligand 8
 NCBI Official Symbol    CXCL8 [Similar Products]
 NCBI Official Synonym Symbols   
IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
[Similar Products]
 NCBI Protein Information    interleukin-8
 UniProt Protein Name    Interleukin-8
 UniProt Synonym Protein Names   
C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; Granulocyte chemotactic protein 1; GCP-1
 Protein Family    Interleukin
 UniProt Gene Name    CXCL8 [Similar Products]
 UniProt Synonym Gene Names    IL8; IL-8; GCP-1; MDNCF; MONAP; NAP-1; LYNAP; NAF [Similar Products]
 UniProt Entry Name    IL8_HUMAN
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 NCBI Summary for IL-8    The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL-8    IL8: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. Belongs to the intercrine alpha (chemokine CxC) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q13-q21

Cellular Component: extracellular region

Molecular Function: chemokine activity; interleukin-8 receptor binding; protein binding

Biological Process: angiogenesis; calcium-mediated signaling; cell cycle arrest; cell motility; chemotaxis; embryonic gut development; G-protein coupled receptor protein signaling pathway; immune response; induction of positive chemotaxis; inflammatory response; negative regulation of cell proliferation; negative regulation of G-protein coupled receptor protein signaling pathway; neutrophil activation; neutrophil chemotaxis; positive regulation of angiogenesis; receptor internalization; regulation of cell adhesion; regulation of retroviral genome replication; response to molecule of bacterial origin; signal transduction
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Product References and Citations for IL-8 western blot control

   Baggiolini, M & Clark-Lewis I (1992) FEBS Letters 307 (1): 97-101.
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 Research Articles on IL-8    1. Weight gain>5% was found in only 35.3% of the cases with NEC-III; combination of weight gain and IL-8 did not improve the diagnosis of NEC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IL-8 western blot controlPathways associated with IL-8 western blot control
 Reference Product  PubMed Publications
 IL8 western blot control  >320 publications with IL-8 and IL8
 CXCR2 western blot control  >244 publications with IL-8 and CXCR2
 CXCR1 western blot control  >221 publications with IL-8 and CXCR1
 JUN western blot control  >186 publications with IL-8 and JUN
 CXCL12 western blot control  >99 publications with IL-8 and CXCL12
 RELA western blot control  >25 publications with IL-8 and RELA
 EGFR western blot control  >24 publications with IL-8 and EGFR
 FOS western blot control  >9 publications with IL-8 and FOS
 DARC western blot control  >8 publications with IL-8 and DARC
 NFKB1 western blot control  >5 publications with IL-8 and NFKB1
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Diseases associated with IL-8 western blot controlOrgans/Tissues associated with IL-8 western blot control
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >783 publications with IL-8 and Inflammation
 Necrosis Antibodies  >377 publications with IL-8 and Necrosis
 Pulmonary Disease, Chronic Obstructive Antibodies  >102 publications with IL-8 and Pulmonary Disease, Chronic Obstructive
 Arthritis, Rheumatoid Antibodies  >61 publications with IL-8 and Arthritis, Rheumatoid
 Adenocarcinoma Antibodies  >42 publications with IL-8 and Adenocarcinoma
 Breast Neoplasms Antibodies  >30 publications with IL-8 and Breast Neoplasms
 Kidney Diseases Antibodies  >24 publications with IL-8 and Kidney Diseases
 Colorectal Neoplasms Antibodies  >20 publications with IL-8 and Colorectal Neoplasms
 Pulmonary Fibrosis Antibodies  >19 publications with IL-8 and Pulmonary Fibrosis
 Fever Antibodies  >18 publications with IL-8 and Fever
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >881 publications with IL-8 and Blood
 Lung Antibodies  >303 publications with IL-8 and Lung
 Vascular Antibodies  >229 publications with IL-8 and Vascular
 Skin Antibodies  >139 publications with IL-8 and Skin
 Bone Antibodies  >83 publications with IL-8 and Bone
 Brain Antibodies  >68 publications with IL-8 and Brain
 Heart Antibodies  >66 publications with IL-8 and Heart
 Muscle Antibodies  >65 publications with IL-8 and Muscle
 Intestine Antibodies  >61 publications with IL-8 and Intestine
 Bone Marrow Antibodies  >55 publications with IL-8 and Bone Marrow
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