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PO-1 western blot control :: Paraoxonase 1 (PO-1) Western Blot Control

Scan QR to view Datasheet Catalog #    MBS343102 PO-1 western blot control
Unit / Price
0.01 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Paraoxonase 1 (PO-1), Western Blot Control

★Popular Item★
 Also Known As   

Paraoxonase 1 (PO-1) (Western Blot Control)

 Product Synonym Names    PON 1, Arylesterase, Esterase A, ESA
 Product Gene Name   

PO-1 western blot control

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    168820
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 Purity/Purification    >= 95% (SDS PAGE)
 Form/Format    Liquid
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 Buffer    Buffered 50% glycerol
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 ISO Certification    Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
 Other Notes    Small volumes of PO-1 western blot control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PO-1 western blot control

   Paraoxonase 1 is involved in the detoxification of organophosphate insecticides such as parathion. Paraoxonase 1 may also confer protection against coronary artery disease by destroying proinflammatory oxidized lipids present in oxidized low-density lipoproteins (LDLs). Recombinant human PON1 is expressed in E Coli with an amino-terminal hexahistidine tag. This product is not intended for therapeutic use.
 Product Categories/Family for PO-1 western blot control    Recombinant Proteins; Paraoxonase 1
NCBI/Uniprot data below describe general gene information for PO-1. It may not necessarily be applicable to this product.
 NCBI GI #    169396010
 NCBI GeneID    5444
 NCBI Accession #    ACA53454.1 [Other Products]
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 UniProt Secondary Accession #    Q16052; Q6B0J6; Q9UCB1; B2RA40 [Other Products]
 UniProt Related Accession #    P27169 [Other Products]
 Molecular Weight    39,731 Da
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 NCBI Official Full Name    paraoxonase 1, partial
 NCBI Official Synonym Full Names    paraoxonase 1
 NCBI Official Symbol    PON1 [Similar Products]
 NCBI Official Synonym Symbols   
ESA; PON; MVCD5
[Similar Products]
 NCBI Protein Information    serum paraoxonase/arylesterase 1
 UniProt Protein Name    Serum paraoxonase/arylesterase 1
 UniProt Synonym Protein Names   
Aromatic esterase 1; A-esterase 1; K-45; Serum aryldialkylphosphatase 1
 UniProt Gene Name    PON1 [Similar Products]
 UniProt Synonym Gene Names    PON; A-esterase 1 [Similar Products]
 UniProt Entry Name    PON1_HUMAN
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 NCBI Summary for PO-1    The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
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 UniProt Comments for PO-1    PON1: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients. Belongs to the paraoxonase family.

Protein type: EC 3.1.1.81; Lipid-binding; Secreted; EC 3.1.8.1; Motility/polarity/chemotaxis; EC 3.1.1.2; Secreted, signal peptide; Hydrolase; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: extracellular space

Molecular Function: aryldialkylphosphatase activity; arylesterase activity; calcium ion binding; phospholipid binding; protein homodimerization activity

Biological Process: aromatic compound catabolic process; carboxylic acid catabolic process; organophosphate catabolic process; phosphatidylcholine metabolic process; positive regulation of binding; positive regulation of transporter activity; response to toxin

Disease: Microvascular Complications Of Diabetes, Susceptibility To, 5
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Product References and Citations for PO-1 western blot control

   Shih, D.M. et al. (1998) Nature 394: 284-287.
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 Research Articles on PO-1    1. Data suggest that serum PON1 activity is up-regulated in subjects treated with cholesterol-lowering agents (fibrates with/without statins) in prevention of cardiovascular disease (CVD) in patients at risk for CVD. [META-ANALYSIS, REVIEW]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PO-1 western blot controlPathways associated with PO-1 western blot control
 Reference Product  PubMed Publications
 APOE western blot control  >93 publications with PO-1 and APOE
 APOA1 western blot control  >44 publications with PO-1 and APOA1
 CLU western blot control  >11 publications with PO-1 and CLU
 PPARG western blot control  >9 publications with PO-1 and PPARG
 IL6 western blot control  >6 publications with PO-1 and IL6
 LPA western blot control  >4 publications with PO-1 and LPA
 PPARA western blot control  >3 publications with PO-1 and PPARA
 SREBF2 western blot control  >2 publications with PO-1 and SREBF2
 APOA2 western blot control  >2 publications with PO-1 and APOA2
 ALB western blot control  >1 publications with PO-1 and ALB
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Phase I, Non P450 Pathway antibodies  Phase I, Non P450 Pathway Diagram
Diseases associated with PO-1 western blot controlOrgans/Tissues associated with PO-1 western blot control
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >736 publications with PO-1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >572 publications with PO-1 and Atherosclerosis
 Coronary Disease Antibodies  >305 publications with PO-1 and Coronary Disease
 Diabetes Mellitus Antibodies  >195 publications with PO-1 and Diabetes Mellitus
 Inflammation Antibodies  >187 publications with PO-1 and Inflammation
 Coronary Artery Disease Antibodies  >182 publications with PO-1 and Coronary Artery Disease
 Poisoning Antibodies  >93 publications with PO-1 and Poisoning
 Kidney Diseases Antibodies  >92 publications with PO-1 and Kidney Diseases
 Liver Diseases Antibodies  >80 publications with PO-1 and Liver Diseases
 Organophosphate Poisoning Antibodies  >51 publications with PO-1 and Organophosphate Poisoning
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >215 publications with PO-1 and Liver
 Brain Antibodies  >94 publications with PO-1 and Brain
 Lung Antibodies  >50 publications with PO-1 and Lung
 Bone Antibodies  >15 publications with PO-1 and Bone
 Pancreas Antibodies  >8 publications with PO-1 and Pancreas
 Testis Antibodies  >3 publications with PO-1 and Testis
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