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S100 Beta Chain western blot control

Scan QR to view Datasheet Catalog #    MBS343127 S100 Beta Chain western blot control
Unit / Price
0.01 mg  /  $195 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S100 Beta Chain, Western Blot Control

 Also Known As   

S100 Beta Chain (Western Blot Control)

 Product Synonym Names    S100B, NEF, S100, S-100 protein beta chain, S-100 calcium binding protein beta chain, S100 calcium binding protein beta (neural).
 Product Gene Name   

S100 Beta Chain western blot control

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176990
 3D Structure    ModBase 3D Structure for P04271
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 Purity/Purification    >= 95% (SDS PAGE)
 Form/Format    Liquid
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 Buffer    Buffered 50% glycerol
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 ISO Certification    Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
 Other Notes    Small volumes of S100 Beta Chain western blot control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for S100 Beta Chain western blot control

   S100 proteins belong to a family of EF-hand calcium binding proteins that exist mostly as dimers of the 20 currently identified individual S100 monomers. The S100B homodimer is expressed in cells of the central nervous system, glial cells and in certain peripheral cells e.g. Schwann cells, melanocytes, adipocytes and chondrocytes. The determination of S100B in serum levels may be used to monitor the extent of brain injury and malignant melanoma. Recombinant S100 beta-chain comprises a 91 amino acid fragment (2-92) corresponding to processed S100 beta-chain and is expressed in E Coli with an aminoterminal hexahistidine tag. This product is not intended for therapeutic use.
 Product Categories/Family for S100 Beta Chain western blot control    Recombinant Proteins; S100 Beta Chain
NCBI/Uniprot data below describe general gene information for S100 Beta Chain. It may not necessarily be applicable to this product.
 NCBI GI #    49457242
 NCBI GeneID    6285
 NCBI Accession #    CAG46920.1 [Other Products]
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 UniProt Primary Accession #    P04271 [Other Products]
 UniProt Secondary Accession #    D3DSN6 [Other Products]
 UniProt Related Accession #    P04271 [Other Products]
 Molecular Weight    10,713 Da
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 NCBI Official Full Name    S100B
 NCBI Official Synonym Full Names    S100 calcium binding protein B
 NCBI Official Symbol    S100B [Similar Products]
 NCBI Official Synonym Symbols   
NEF; S100; S100-B; S100beta
[Similar Products]
 NCBI Protein Information    protein S100-B
 UniProt Protein Name    Protein S100-B
 UniProt Synonym Protein Names   
S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B
 UniProt Gene Name    S100B [Similar Products]
 UniProt Entry Name    S100B_HUMAN
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 NCBI Summary for S100 Beta Chain    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for S100 Beta Chain    S100B: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. The S100B dimer interacts with two molecules of CAPZA1. Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Belongs to the S-101 family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cytoplasm; extracellular region; intracellular membrane-bound organelle; nucleus; perinuclear region of cytoplasm; ruffle

Molecular Function: calcium-dependent protein binding; identical protein binding; protein binding; protein homodimerization activity; RAGE receptor binding; tau protein binding; zinc ion binding

Biological Process: axonogenesis; cell proliferation; central nervous system development; innate immune response; learning and/or memory; positive regulation of I-kappaB kinase/NF-kappaB cascade
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Product References and Citations for S100 Beta Chain western blot control

   Heizmann, C.W. (1998) Biometals 11 (4): 383-397. Rothermundt, M. et al. (2003) Microsc. Res. Tech. 60 (6): 614-632.
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 Research Articles on S100 Beta Chain    1. There was no association found between serum and CSF S100B with radiographic vasospasm or DIND. S100B is a potential prognostic marker for aSAH outcome
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with S100 Beta Chain western blot controlPathways associated with S100 Beta Chain western blot control
 Reference Product  PubMed Publications
 GFAP western blot control  >209 publications with S100 Beta Chain and GFAP
 S100A1 western blot control  >96 publications with S100 Beta Chain and S100A1
 HMGB1 western blot control  >30 publications with S100 Beta Chain and HMGB1
 FGF2 western blot control  >10 publications with S100 Beta Chain and FGF2
 AGER western blot control  >8 publications with S100 Beta Chain and AGER
 TP53 western blot control  >5 publications with S100 Beta Chain and TP53
 AHNAK western blot control  >3 publications with S100 Beta Chain and AHNAK
 IQGAP1 western blot control  >3 publications with S100 Beta Chain and IQGAP1
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 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 MyD88-independent TLR3/TLR4 Cascade Pathway antibodies  MyD88-independent TLR3/TLR4 Cascade Pathway Diagram
 MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram
Diseases associated with S100 Beta Chain western blot controlOrgans/Tissues associated with S100 Beta Chain western blot control
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >761 publications with S100 Beta Chain and Nervous System Diseases
 Brain Diseases Antibodies  >633 publications with S100 Beta Chain and Brain Diseases
 Cardiovascular Diseases Antibodies  >280 publications with S100 Beta Chain and Cardiovascular Diseases
 Brain Injuries Antibodies  >237 publications with S100 Beta Chain and Brain Injuries
 Inflammation Antibodies  >176 publications with S100 Beta Chain and Inflammation
 Disease Models, Animal Antibodies  >137 publications with S100 Beta Chain and Disease Models, Animal
 Hemorrhage Antibodies  >95 publications with S100 Beta Chain and Hemorrhage
 Heart Diseases Antibodies  >82 publications with S100 Beta Chain and Heart Diseases
 Necrosis Antibodies  >72 publications with S100 Beta Chain and Necrosis
 Cognition Disorders Antibodies  >55 publications with S100 Beta Chain and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1088 publications with S100 Beta Chain and Brain
 Nerve Antibodies  >1054 publications with S100 Beta Chain and Nerve
 Blood Antibodies  >884 publications with S100 Beta Chain and Blood
 Heart Antibodies  >133 publications with S100 Beta Chain and Heart
 Skin Antibodies  >71 publications with S100 Beta Chain and Skin
 Eye Antibodies  >39 publications with S100 Beta Chain and Eye
 Lung Antibodies  >37 publications with S100 Beta Chain and Lung
 Spinal Cord Antibodies  >35 publications with S100 Beta Chain and Spinal Cord
 Embryonic Tissue Antibodies  >19 publications with S100 Beta Chain and Embryonic Tissue
 Adipose Tissue Antibodies  >13 publications with S100 Beta Chain and Adipose Tissue
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