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A1CF cdna clone

Scan QR to view Datasheet Catalog #    MBS1269966 A1CF cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A1CF, cDNA Clone

 Also Known As   

A1CF cDNA Clone

 Product Gene Name   

A1CF cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggaatcaa atcacaaatc cggggatgga ttgagcggca ctcagaagga agcagccctc cgcgcactgg tccagcgcac aggatatagc ttggtccagg aaaatggaca aagaaaatat ggtggccctc cacctggttg ggatgctgca ccccctgaaa ggggctgtga aatttttatt ggaaaacttc cccgagacct ttttgaggat gagcttatac cattatgtga aaaaatcggt aaaatttatg aaatgagaat gatgatggat tttaatggca acaatagagg atatgcattt gtaacatttt caaataaagt ggaagccaag aatgcaatca agcaacttaa taattatgaa attaggtaa
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of A1CF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for A1CF. It may not necessarily be applicable to this product.
 NCBI GI #    33392738
 NCBI GeneID    29974
 NCBI Accession #    BC054873 [Other Products]
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 UniProt Secondary Accession #    Q5SZQ0; Q9NQ93; Q9NQX8; Q9NQX9; Q9NXC9; Q9NZD3; A1L4F2; A8K7G7; B7ZM14 [Other Products]
 UniProt Related Accession #    Q9NQ94 [Other Products]
 Molecular Weight    58,871 Da
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 NCBI Official Full Name    Homo sapiens APOBEC1 complementation factor, mRNA
 NCBI Official Synonym Full Names    APOBEC1 complementation factor
 NCBI Official Symbol    A1CF [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    APOBEC1 complementation factor
 UniProt Protein Name    APOBEC1 complementation factor
 UniProt Synonym Protein Names   
APOBEC1-stimulating protein
 Protein Family    APOBEC1 complementation factor
 UniProt Gene Name    A1CF [Similar Products]
 UniProt Synonym Gene Names    [Similar Products]
 UniProt Entry Name    A1CF_HUMAN
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 NCBI Summary for A1CF    Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
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 UniProt Comments for A1CF    ACF: Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; RNA-binding; RNA processing

Chromosomal Location of Human Ortholog: 10q11.23

Cellular Component: apolipoprotein B mRNA editing enzyme complex; cytoplasm; nucleoplasm

Molecular Function: double-stranded RNA binding; protein binding; RNA binding; single-stranded RNA binding

Biological Process: cytidine to uridine editing; protein stabilization
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 Research Articles on A1CF    1. hnRNP K and hnRNP L may serve as A1CF-like cofactors in AID-mediated class switch recombination and somatic hypermutation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with A1CF cdna cloneDiseases associated with A1CF cdna clone
 Products by Pathway  Pathway Diagram
 Formation Of The Editosome Pathway antibodies  Formation Of The Editosome Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 MRNA Editing Pathway antibodies  MRNA Editing Pathway Diagram
 MRNA Editing: C To U Conversion Pathway antibodies  MRNA Editing: C To U Conversion Pathway Diagram
 Disease Name  Pubmed Publications
 Metabolic Diseases Antibodies  >3 publications with A1CF and Metabolic Diseases
 Gout Antibodies  >1 publications with A1CF and Gout
 Liver Diseases Antibodies  >1 publications with A1CF and Liver Diseases
 Autoimmune Diseases Antibodies  >1 publications with A1CF and Autoimmune Diseases
 Kidney Diseases Antibodies  >1 publications with A1CF and Kidney Diseases
 Neoplasms Antibodies  >1 publications with A1CF and Neoplasms
Organs/Tissues associated with A1CF cdna clone
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with A1CF and Liver
 Kidney Antibodies  >3 publications with A1CF and Kidney
 Intestine Antibodies  >3 publications with A1CF and Intestine
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