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AADAT cdna clone

Scan QR to view Datasheet Catalog #    MBS1270390 AADAT cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AADAT, cDNA Clone

★Popular Item★
 Also Known As   

AADAT cDNA Clone

 Product Gene Name   

AADAT cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgaattacg cacggttcat cacggcagcg agcgcagcca gaaacccttc tcccatccgg accatgagtg agaaacgggc tgacatattg agcagaggac caaaatcgat gatctccttg gctggtggct taccaaatcc aaacatgttt ccttttaaga ctgccgtaat cactgtagaa aatggaaaga ccatccaatt tggagaagag atgatgaaga gagcacttca gtattctccg agtgctggaa ttccagagct tttgtcctgg ctaaaacagt tacaaataaa attgcataat cctcctacca tccattacca acccagtcaa ggacaaatgg atctatgtgt cacatctggc agccaacaag gtctttgtaa ggtgtttgaa atgatcatta atcctggaga taatgtcctc ctagatgaac ctgcttattc aggaactctt caaagtctgc acccactggg ctgcaacatt attaatgttg ccagtgatga aagtgggatt gttccagatt ccctaagaga catactttcc agatggaaac cagaagatgc aaagaatccc cagaaaaaca cccccaaatt tctttatact gttccaaatg gcaacaaccc tactggaaac tcattaacca gtgaacgcaa aaaggaaatc tatgagcttg caagaaaata tgatttcctc ataatagaag atgatcctta ctattttctc cagtttaaca agttcagggt accaacattt ctttccatgg atgttgatgg acgtgtcatc agagctgact ctttttcaaa aatcatttcc tctgggttga gaataggatt tttaactggt ccaaaaccct taatagagag agttatttta cacatacaag tttcaacatt gcaccccagc acttttaacc agctcatgat atcacagctt ctacacgaat ggggagaaga aggtttcatg gctcatgtag acagggttat tgatttctat agtaaccaga aggatgcaat actggcagct gcagacaagt ggttaactgg tttggcagaa tggcatgttc ctgctgctgg aatgttttta tggattaaag ttaaaggcat taatgatgta aaagaactga ttgaagaaaa ggccgttaag atgggggtat taatgctccc tggaaatgct ttctacgtcg atagctcagc tcctagccct tacttgagag catccttctc ttcagcttct ccagaacaga tggatgtggc cttccaggta ttagcacaac ttataaaaga atctttatga
 OMIM    611754
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AADAT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for AADAT. It may not necessarily be applicable to this product.
 NCBI GI #    21410575
 NCBI GeneID    51166
 NCBI Accession #    BC031068 [Other Products]
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 UniProt Secondary Accession #    Q9UL02; B3KP84 [Other Products]
 UniProt Related Accession #    Q8N5Z0 [Other Products]
 Molecular Weight    47,822 Da
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 NCBI Official Full Name    Homo sapiens aminoadipate aminotransferase, mRNA
 NCBI Official Synonym Full Names    aminoadipate aminotransferase
 NCBI Official Symbol    AADAT [Similar Products]
 NCBI Official Synonym Symbols   
KAT2; KATII; KYAT2
[Similar Products]
 NCBI Protein Information    kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
 UniProt Protein Name    Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
 UniProt Synonym Protein Names   
2-aminoadipate aminotransferase; 2-aminoadipate transaminase (EC:2.6.1.39); Alpha-aminoadipate aminotransferase; AadAT; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2 (EC:2.6.1.7); Kynurenine--oxoglutarate transaminase II
 Protein Family    Kynurenine/alpha-aminoadipate aminotransferase
 UniProt Gene Name    AADAT [Similar Products]
 UniProt Synonym Gene Names    KAT2; KAT/AadAT; AadAT [Similar Products]
 UniProt Entry Name    AADAT_HUMAN
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 NCBI Summary for AADAT    This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
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 UniProt Comments for AADAT    AADAT: Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; EC 2.6.1.7; Amino Acid Metabolism - lysine biosynthesis; EC 2.6.1.39; Transferase; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - lysine degradation

Chromosomal Location of Human Ortholog: 4q33

Cellular Component: mitochondrial matrix

Molecular Function: 2-aminoadipate transaminase activity; kynurenine-oxoglutarate transaminase activity; protein homodimerization activity

Biological Process: 2-oxoglutarate metabolic process; glutamate metabolic process; lysine catabolic process; tryptophan catabolic process
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 Research Articles on AADAT    1. Participants with major depression had lower levels of kynurenine compared to controls, with intermediate concentrations in somatoform patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with AADAT cdna cloneOrgans/Tissues associated with AADAT cdna clone
 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Lysine Biosynthesis Pathway antibodies  Lysine Biosynthesis Pathway Diagram
 Lysine Biosynthesis Pathway antibodies  Lysine Biosynthesis Pathway Diagram
 Lysine Catabolism Pathway antibodies  Lysine Catabolism Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation, Lysine => Saccharopine => Acetoacetyl-CoA Pathway antibodies  Lysine Degradation, Lysine => Saccharopine => Acetoacetyl-CoA Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >6 publications with AADAT and Kidney
 Liver Antibodies  >4 publications with AADAT and Liver
 Brain Antibodies  >2 publications with AADAT and Brain
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