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AAK1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1277547 AAK1 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AAK1, cDNA Clone

 Also Known As   

AAK1 cDNA Clone

 Product Gene Name   

AAK1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    616405
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AAK1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for AAK1. It may not necessarily be applicable to this product.
 NCBI GI #    38114742
 NCBI GeneID    22848
 NCBI Accession #    BC002695 [Other Products]
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 UniProt Secondary Accession #    Q4ZFZ3; Q53RX6; Q9UPV4 [Other Products]
 UniProt Related Accession #    Q2M2I8 [Other Products]
 Molecular Weight    93,578 Da
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 NCBI Official Full Name    Homo sapiens AP2 associated kinase 1, mRNA
 NCBI Official Synonym Full Names    AP2 associated kinase 1
 NCBI Official Symbol    AAK1 [Similar Products]
 NCBI Protein Information    AP2-associated protein kinase 1
 UniProt Protein Name    AP2-associated protein kinase 1
 UniProt Synonym Protein Names   
Adaptor-associated kinase 1
 Protein Family    AP2-associated protein kinase
 UniProt Gene Name    AAK1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1048 [Similar Products]
 UniProt Entry Name    AAK1_HUMAN
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 NCBI Summary for AAK1    Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AAK1    AAK1: an NAK kinase. Plays a regulatory role in clathrin-mediated endocytosis, including the regulation of fatty acid synthesis and cholesterol synthesis.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Other group; NAK family

Chromosomal Location of Human Ortholog: 2p14

Cellular Component: clathrin-coated vesicle; cytoplasm; extrinsic to plasma membrane; leading edge; terminal button

Molecular Function: Notch binding; protein binding; protein serine/threonine kinase activity

Biological Process: positive regulation of Notch signaling pathway; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein stabilization; regulation of protein localization
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 Research Articles on AAK1    1. Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with AAK1 cdna cloneOrgans/Tissues associated with AAK1 cdna clone
 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >2 publications with AAK1 and Drug Toxicity
 Brain Diseases Antibodies  >1 publications with AAK1 and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1 publications with AAK1 and Neurodegenerative Diseases
 Neoplasms Antibodies  >1 publications with AAK1 and Neoplasms
 Inflammation Antibodies  >1 publications with AAK1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >6 publications with AAK1 and Nerve
 Brain Antibodies  >4 publications with AAK1 and Brain
 Blood Antibodies  >3 publications with AAK1 and Blood
 Kidney Antibodies  >2 publications with AAK1 and Kidney
 Heart Antibodies  >1 publications with AAK1 and Heart
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