BC002695
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
93,578 Da
NCBI Official Full Name
Homo sapiens AP2 associated kinase 1, mRNA
NCBI Official Synonym Full Names
AP2 associated kinase 1
NCBI Protein Information
AP2-associated protein kinase 1
UniProt Protein Name
AP2-associated protein kinase 1
UniProt Synonym Protein Names
Adaptor-associated kinase 1
UniProt Synonym Gene Names
UniProt Entry Name
AAK1_HUMAN
NCBI Summary for AAK1
Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for AAK1
AAK1: an NAK kinase. Plays a regulatory role in clathrin-mediated endocytosis, including the regulation of fatty acid synthesis and cholesterol synthesis.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Other group; NAK family
Chromosomal Location of Human Ortholog: 2p14
Cellular Component: clathrin-coated vesicle; cytoplasm; extrinsic to plasma membrane; leading edge; terminal button
Molecular Function: Notch binding; protein binding; protein serine/threonine kinase activity
Biological Process: positive regulation of Notch signaling pathway; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein stabilization; regulation of protein localization
Research Articles on AAK1
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Diseases associated with AAK1 cdna clone
Organs/Tissues associated with AAK1 cdna clone
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