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AANAT cdna clone

Scan QR to view Datasheet Catalog #    MBS1268531 AANAT cdna clone
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   


 Product Gene Name   

AANAT cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    600950
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AANAT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for AANAT. It may not necessarily be applicable to this product.
 NCBI GI #    46854803
 NCBI GeneID    15
 NCBI Accession #    BC069434 [Other Products]
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 UniProt Secondary Accession #    Q562F4; A0AVF2; J3KMZ5 [Other Products]
 UniProt Related Accession #    Q16613 [Other Products]
 Molecular Weight    28,432 Da
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 NCBI Official Full Name    Homo sapiens arylalkylamine N-acetyltransferase, mRNA
 NCBI Official Synonym Full Names    aralkylamine N-acetyltransferase
 NCBI Official Symbol    AANAT [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    serotonin N-acetyltransferase
 UniProt Protein Name    Serotonin N-acetyltransferase
 UniProt Synonym Protein Names   
Aralkylamine N-acetyltransferase; AA-NAT
 Protein Family    Serotonin N-acetyltransferase
 UniProt Gene Name    AANAT [Similar Products]
 UniProt Synonym Gene Names    SNAT; Serotonin acetylase; AA-NAT [Similar Products]
 UniProt Entry Name    SNAT_HUMAN
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 NCBI Summary for AANAT    The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
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 UniProt Comments for AANAT    AA-NAT var1: Catalyzes the N-acetylation of serotonin into N- acetylserotonin. Controls the night/day rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated versus non-hydroxylated arylalkylamines. Belongs to the acetyltransferase family. AANAT subfamily. Monomer. Interacts with YWHAZ; the interaction requires phosphorylation on Thr-31, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-205 site, the other YWHAZ monomer with similar effect.

Protein type: Acetyltransferase; Amino Acid Metabolism - tryptophan; EC

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: cytosol; perinuclear region of cytoplasm

Molecular Function: aralkylamine N-acetyltransferase activity; protein binding

Biological Process: circadian rhythm; indolalkylamine biosynthetic process; melatonin biosynthetic process; N-terminal protein amino acid acetylation; response to light stimulus

Disease: Delayed Sleep Phase Syndrome, Susceptibility To
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 Research Articles on AANAT    1. There is dysregulation of the AANAT/ASMT/melatonin --> melatonin receptor axis in cholangiocarcinoma, which inhibited melatonin secretion and subsequently enhanced CCA growth.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with AANAT cdna cloneDiseases associated with AANAT cdna clone
 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Melatonin Biosynthesis, Tryptophan => Serotonin => Melatonin Pathway antibodies  Melatonin Biosynthesis, Tryptophan => Serotonin => Melatonin Pathway Diagram
 Melatonin Biosynthesis, Tryptophan => Serotonin => Melatonin Pathway antibodies  Melatonin Biosynthesis, Tryptophan => Serotonin => Melatonin Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Serotonin And Melatonin Biosynthesis Pathway antibodies  Serotonin And Melatonin Biosynthesis Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >4 publications with AANAT and Brain Diseases
 Mental Disorders Antibodies  >3 publications with AANAT and Mental Disorders
 Mood Disorders Antibodies  >3 publications with AANAT and Mood Disorders
 Kidney Diseases Antibodies  >1 publications with AANAT and Kidney Diseases
 Movement Disorders Antibodies  >1 publications with AANAT and Movement Disorders
 Hypothermia Antibodies  >1 publications with AANAT and Hypothermia
 Basal Ganglia Diseases Antibodies  >1 publications with AANAT and Basal Ganglia Diseases
 Necrosis Antibodies  >1 publications with AANAT and Necrosis
Organs/Tissues associated with AANAT cdna clone
 Organ/Tissue Name  Pubmed Publications
 Pineal Gland Antibodies  >121 publications with AANAT and Pineal Gland
 Eye Antibodies  >59 publications with AANAT and Eye
 Testis Antibodies  >3 publications with AANAT and Testis
 Ovary Antibodies  >2 publications with AANAT and Ovary
 Kidney Antibodies  >1 publications with AANAT and Kidney
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