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AATF cdna clone

Scan QR to view Datasheet Catalog #    MBS1275193 AATF cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AATF, cDNA Clone

 Also Known As   


 Product Gene Name   

AATF cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    608463
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AATF cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for AATF. It may not necessarily be applicable to this product.
 NCBI GI #    33875610
 NCBI GeneID    26574
 NCBI Accession #    BC000591 [Other Products]
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 UniProt Secondary Accession #    Q9P0A4; Q9UNX5; A6NCJ6; B3KQ26 [Other Products]
 UniProt Related Accession #    Q9NY61 [Other Products]
 Molecular Weight    63,133 Da
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 NCBI Official Full Name    Homo sapiens apoptosis antagonizing transcription factor, mRNA
 NCBI Official Synonym Full Names    apoptosis antagonizing transcription factor
 NCBI Official Symbol    AATF [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    protein AATF
 UniProt Protein Name    Protein AATF
 UniProt Synonym Protein Names   
Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1
 Protein Family    Protein
 UniProt Gene Name    AATF [Similar Products]
 UniProt Synonym Gene Names    CHE1; DED [Similar Products]
 UniProt Entry Name    AATF_HUMAN
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 NCBI Summary for AATF    The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AATF    AATF: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Belongs to the AATF family.

Protein type: Transcription factor; RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: centrosome; cytoplasm; focal adhesion; nucleolus; nucleus

Molecular Function: leucine zipper domain binding; protein binding

Biological Process: negative regulation of apoptosis; negative regulation of superoxide release; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus
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 Research Articles on AATF    1. It was concluded that PARP-1 was involved in the DNA damage repair induced by HQ via increasing the accumulation of apoptosis antagonizing transcription factor through PARylation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with AATF cdna cloneDiseases associated with AATF cdna clone
 Products by Pathway  Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 NRAGE Signals Death Through JNK Pathway antibodies  NRAGE Signals Death Through JNK Pathway Diagram
 Regulation Of Retinoblastoma Protein Pathway antibodies  Regulation Of Retinoblastoma Protein Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 P75 NTR Receptor-mediated Signalling Pathway antibodies  P75 NTR Receptor-mediated Signalling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with AATF and Neoplasms
 Lymphoma Antibodies  >3 publications with AATF and Lymphoma
 Breast Neoplasms Antibodies  >2 publications with AATF and Breast Neoplasms
 Inflammation Antibodies  >2 publications with AATF and Inflammation
 Liver Neoplasms, Experimental Antibodies  >1 publications with AATF and Liver Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >1 publications with AATF and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >1 publications with AATF and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with AATF and Liver Neoplasms
 Necrosis Antibodies  >1 publications with AATF and Necrosis
Organs/Tissues associated with AATF cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with AATF and Brain
 Liver Antibodies  >6 publications with AATF and Liver
 Prostate Antibodies  >4 publications with AATF and Prostate
 Blood Antibodies  >4 publications with AATF and Blood
 Kidney Antibodies  >4 publications with AATF and Kidney
 Heart Antibodies  >3 publications with AATF and Heart
 Muscle Antibodies  >3 publications with AATF and Muscle
 Embryonic Tissue Antibodies  >2 publications with AATF and Embryonic Tissue
 Lung Antibodies  >2 publications with AATF and Lung
 Intestine Antibodies  >1 publications with AATF and Intestine
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