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ABCA1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1267165
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCA1, cDNA Clone

 Also Known As   

ABCA1 cDNA Clone

 Product Gene Name   

ABCA1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    205400
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ABCA1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Vector Map of ABCA1 cdna clone    ABCA1 cdna clone Vector Map image
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NCBI/Uniprot data below describe general gene information for ABCA1. It may not necessarily be applicable to this product.
 NCBI GI #    146327015
 NCBI GeneID    19
 NCBI Accession #    BC141816 [Other Products]
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 UniProt Secondary Accession #    Q5VX33; Q96S56; Q96T85; Q9NQV4; Q9UN06; Q9UN07; Q9UN08; Q9UN09 [Other Products]
 UniProt Related Accession #    O95477 [Other Products]
 Molecular Weight    254,302 Da
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 NCBI Official Full Name    Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 1, mRNA
 NCBI Official Synonym Full Names    ATP binding cassette subfamily A member 1
 NCBI Official Symbol    ABCA1 [Similar Products]
 NCBI Official Synonym Symbols   
TGD; ABC1; CERP; ABC-1; HDLDT1
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family A member 1
 UniProt Protein Name    ATP-binding cassette sub-family A member 1
 UniProt Synonym Protein Names   
ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein
 Protein Family    ABC transporter A family
 UniProt Gene Name    ABCA1 [Similar Products]
 UniProt Synonym Gene Names    ABC1; CERP; ABC-1; ATP-binding cassette 1 [Similar Products]
 UniProt Entry Name    ABCA1_HUMAN
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 NCBI Summary for ABCA1    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCA1    ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies.

Protein type: Vesicle; Transporter; Transporter, ABC family; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: endocytic vesicle; endoplasmic reticulum membrane; integral to plasma membrane; lipid raft; perinuclear region of cytoplasm; phagocytic vesicle; plasma membrane

Molecular Function: anion transmembrane transporter activity; apolipoprotein A-I binding; apolipoprotein A-I receptor activity; apolipoprotein binding; ATP binding; ATPase activity, coupled to transmembrane movement of substances; ATPase binding; cholesterol binding; cholesterol transporter activity; phospholipid binding; phospholipid transporter activity; protein binding; receptor binding; small GTPase binding; syntaxin binding

Biological Process: cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; endosome transport; G-protein coupled receptor protein signaling pathway; interleukin-1 beta secretion; intracellular cholesterol transport; lipoprotein metabolic process; lysosome organization and biogenesis; phospholipid efflux; phospholipid homeostasis; platelet dense granule organization and biogenesis; positive regulation of cAMP biosynthetic process; regulation of Cdc42 protein signal transduction; response to low density lipoprotein stimulus; reverse cholesterol transport

Disease: Hypercholesterolemia, Familial; Hypoalphalipoproteinemia, Primary; Tangier Disease
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 Research Articles on ABCA1    1. PGG enhances expression of SR-BI and ABCA1 in J774 and THP-1 macrophages
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ABCA1 cdna cloneDiseases associated with ABCA1 cdna clone
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >597 publications with ABCA1 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >438 publications with ABCA1 and Cardiovascular Diseases
 Dyslipidemias Antibodies  >225 publications with ABCA1 and Dyslipidemias
 Tangier Disease Antibodies  >195 publications with ABCA1 and Tangier Disease
 Inflammation Antibodies  >155 publications with ABCA1 and Inflammation
 Coronary Disease Antibodies  >151 publications with ABCA1 and Coronary Disease
 Familial HDL deficiency Antibodies  >138 publications with ABCA1 and Familial HDL deficiency
 Hypoalphalipoproteinemias Antibodies  >121 publications with ABCA1 and Hypoalphalipoproteinemias
 Heart Diseases Antibodies  >118 publications with ABCA1 and Heart Diseases
 Peripheral Nervous System Diseases Antibodies  >114 publications with ABCA1 and Peripheral Nervous System Diseases
Organs/Tissues associated with ABCA1 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >681 publications with ABCA1 and Liver
 Blood Antibodies  >595 publications with ABCA1 and Blood
 Vascular Antibodies  >229 publications with ABCA1 and Vascular
 Brain Antibodies  >138 publications with ABCA1 and Brain
 Intestine Antibodies  >93 publications with ABCA1 and Intestine
 Kidney Antibodies  >75 publications with ABCA1 and Kidney
 Lung Antibodies  >63 publications with ABCA1 and Lung
 Muscle Antibodies  >62 publications with ABCA1 and Muscle
 Bone Antibodies  >54 publications with ABCA1 and Bone
 Bone Marrow Antibodies  >51 publications with ABCA1 and Bone Marrow
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