BC104894
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,832 Da
NCBI Official Full Name
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 5, mRNA
NCBI Official Synonym Full Names
ATP binding cassette subfamily B member 5
NCBI Official Synonym Symbols
ABCB5beta; EST422562; ABCB5alpha [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family B member 5
UniProt Protein Name
ATP-binding cassette sub-family B member 5
UniProt Synonym Protein Names
ABCB5 P-gp; P-glycoprotein ABCB5
UniProt Entry Name
ABCB5_HUMAN
NCBI Summary for ABCB5
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]
UniProt Comments for ABCB5
ABCB5: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 7p21.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; efflux transmembrane transporter activity; xenobiotic-transporting ATPase activity
Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; compound eye corneal lens development; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; regulation of membrane potential; transmembrane transport
Research Articles on ABCB5
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with ABCB5 cdna clone
Diseases associated with ABCB5 cdna clone
Organs/Tissues associated with ABCB5 cdna clone
|