BC017348
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
77,470 Da
NCBI Official Full Name
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 9, mRNA
NCBI Official Synonym Full Names
ATP binding cassette subfamily B member 9
NCBI Protein Information
ATP-binding cassette sub-family B member 9
UniProt Protein Name
ATP-binding cassette sub-family B member 9
UniProt Synonym Protein Names
ATP-binding cassette transporter 9; ABC transporter 9 protein; hABCB9; TAP-like protein; TAPL
UniProt Synonym Gene Names
UniProt Entry Name
ABCB9_HUMAN
NCBI Summary for ABCB9
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]
UniProt Comments for ABCB9
ABCB9: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored. Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ABC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q24
Cellular Component: early endosome; endoplasmic reticulum; integral to endoplasmic reticulum membrane; integral to membrane; lysosomal membrane; lysosome
Molecular Function: ATP binding; oligopeptide-transporting ATPase activity; peptide-transporting ATPase activity; protein binding; protein homodimerization activity; substrate-specific transmembrane transporter activity
Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; peptide transport; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; transmembrane transport
Research Articles on ABCB9
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Pathways associated with ABCB9 cdna clone
Organs/Tissues associated with ABCB9 cdna clone
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