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ABCC11 cdna clone

Scan QR to view Datasheet Catalog #    MBS1268541 ABCC11 cdna clone
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCC11, cDNA Clone

 Also Known As   

ABCC11 cDNA Clone

 Product Gene Name   

ABCC11 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    117800
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ABCC11 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ABCC11. It may not necessarily be applicable to this product.
 NCBI GI #    24660219
 NCBI GeneID    85320
 NCBI Accession #    BC039085 [Other Products]
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 UniProt Secondary Accession #    Q8TDJ0; Q96JA6; Q9BX80 [Other Products]
 UniProt Related Accession #    Q96J66 [Other Products]
 Molecular Weight    150,093 Da
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 NCBI Official Full Name    Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 11, mRNA
 NCBI Official Synonym Full Names    ATP binding cassette subfamily C member 11
 NCBI Official Symbol    ABCC11 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family C member 11
 UniProt Protein Name    ATP-binding cassette sub-family C member 11
 UniProt Synonym Protein Names   
Multidrug resistance-associated protein 8
 Protein Family    ABC transporter C family
 UniProt Gene Name    ABCC11 [Similar Products]
 UniProt Synonym Gene Names    MRP8 [Similar Products]
 UniProt Entry Name    ABCCB_HUMAN
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 NCBI Summary for ABCC11    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCC11    ABCC11: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter; Transporter, ABC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: anion transmembrane-transporting ATPase activity; organic anion transmembrane transporter activity; purine nucleotide transmembrane transporter activity

Biological Process: organic anion transport; purine nucleotide transport; transmembrane transport

Disease: Apocrine Gland Secretion, Variation In
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 Research Articles on ABCC11    1. MRP8 elevated serum levels in patients with Behcet's disease indicate MRP8 role in the pathogenetic mechanisms of Behcet's disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ABCC11 cdna cloneDiseases associated with ABCC11 cdna clone
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >27 publications with ABCC11 and Neoplasms
 Skin Diseases Antibodies  >16 publications with ABCC11 and Skin Diseases
 Breast Neoplasms Antibodies  >13 publications with ABCC11 and Breast Neoplasms
 Necrosis Antibodies  >6 publications with ABCC11 and Necrosis
 Nervous System Diseases Antibodies  >4 publications with ABCC11 and Nervous System Diseases
 Adenocarcinoma Antibodies  >4 publications with ABCC11 and Adenocarcinoma
 Lung Diseases Antibodies  >3 publications with ABCC11 and Lung Diseases
 Liver Diseases Antibodies  >2 publications with ABCC11 and Liver Diseases
 Hematologic Diseases Antibodies  >2 publications with ABCC11 and Hematologic Diseases
 Brain Diseases Antibodies  >2 publications with ABCC11 and Brain Diseases
Organs/Tissues associated with ABCC11 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Mammary Gland Antibodies  >3 publications with ABCC11 and Mammary Gland
 Intestine Antibodies  >2 publications with ABCC11 and Intestine
 Testis Antibodies  >2 publications with ABCC11 and Testis
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