BC039085
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
150,093 Da
NCBI Official Full Name
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 11, mRNA
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 11
NCBI Protein Information
ATP-binding cassette sub-family C member 11
UniProt Protein Name
ATP-binding cassette sub-family C member 11
UniProt Synonym Protein Names
Multidrug resistance-associated protein 8
UniProt Synonym Gene Names
UniProt Entry Name
ABCCB_HUMAN
NCBI Summary for ABCC11
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC11
ABCC11: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter; Transporter, ABC family; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 16q12.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: anion transmembrane-transporting ATPase activity; organic anion transmembrane transporter activity; purine nucleotide transmembrane transporter activity
Biological Process: organic anion transport; purine nucleotide transport; transmembrane transport
Disease: Apocrine Gland Secretion, Variation In
Research Articles on ABCC11
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Pathways associated with ABCC11 cdna clone
Diseases associated with ABCC11 cdna clone
Organs/Tissues associated with ABCC11 cdna clone
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