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ABCC9 cdna clone

Scan QR to view Datasheet Catalog #    MBS1275236 ABCC9 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCC9, cDNA Clone

★Popular Item★
 Also Known As   

ABCC9 cDNA Clone

 Product Gene Name   

ABCC9 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgagccttt cattttgtgg taacaacatt tcttcatata atatcaacga tggtgtacta caaaattcct gctttgtgga tgccctcaac ctggtccctc atgtctttct gttgtttatc acttttccaa tattgtttat tgggtggggg agccaaagct caaaagtaca aattcaccac aacacatggc ttcattttcc gggacataac ctgagatgga ttcttacatt cgctctcctg tttgtgcatg tctgtgaaat agcagaaggc attgtttcag actcgcggcg ggaatcaagg cacctccacc tctttatgcc agccgtgatg ggattcgttg ccactacaac atcgatagtg tattatcata atatcgaaac atcaaatttt cctaaattac ttttaggttt tagccatcat gagagtaaaa gctgctatca acattcttaa
 OMIM    239850
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ABCC9 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ABCC9. It may not necessarily be applicable to this product.
 NCBI GI #    21708092
 NCBI GeneID    10060
 NCBI Accession #    BC033804 [Other Products]
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 UniProt Secondary Accession #    O60707 [Other Products]
 UniProt Related Accession #    O60706 [Other Products]
 Molecular Weight    174,425 Da
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 NCBI Official Full Name    Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 9, mRNA
 NCBI Official Synonym Full Names    ATP binding cassette subfamily C member 9
 NCBI Official Symbol    ABCC9 [Similar Products]
 NCBI Official Synonym Symbols   
SUR2; ABC37; CANTU; CMD1O; ATFB12
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family C member 9
 UniProt Protein Name    ATP-binding cassette sub-family C member 9
 UniProt Synonym Protein Names   
Sulfonylurea receptor 2
 Protein Family    ABC transporter C family
 UniProt Gene Name    ABCC9 [Similar Products]
 UniProt Synonym Gene Names    SUR2 [Similar Products]
 UniProt Entry Name    ABCC9_HUMAN
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 NCBI Summary for ABCC9    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]
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 UniProt Comments for ABCC9    ABCC9: Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Defects in ABCC9 are the cause of cardiomyopathy dilated type 1O (CMD1O); also known as dilated cardiomyopathy with ventricular tachycardia. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in ABCC9 are the cause of familial atrial fibrillation type 12 (ATFB12). ATFB12 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Defects in ABCC9 are the cause of hypertrichotic osteochondrodysplasia (HTOCD). A rare disorder characterized by congenital hypertrichosis, neonatal macrosomia, a distinct osteochondrodysplasia, and cardiomegaly. The hypertrichosis leads to thick scalp hair, which extends onto the forehead, and a general increase in body hair. In addition, macrocephaly and coarse facial features, including a broad nasal bridge, epicanthal folds, a wide mouth, and full lips, can be suggestive of a storage disorder. About half of affected individuals are macrosomic and edematous at birth, whereas in childhood they usually have a muscular appearance with little subcutaneous fat. Thickened calvarium, narrow thorax, wide ribs, flattened or ovoid vertebral bodies, coxa valga, osteopenia, enlarged medullary canals, and metaphyseal widening of long bones have been reported. Cardiac manifestations such as patent ductus arteriosus, ventricular hypertrophy, pulmonary hypertension, and pericardial effusions are present in approximately 80% of cases. Motor development is usually delayed due to hypotonia. Most patients have a mild speech delay, and a small percentage have learning difficulties or intellectual disability. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, ABC family

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: ATP-sensitive potassium channel complex; plasma membrane; voltage-gated potassium channel complex

Molecular Function: anion transmembrane-transporting ATPase activity; potassium channel regulator activity; sulfonylurea receptor activity; transporter activity

Biological Process: defense response to virus; potassium ion import; potassium ion transport; transmembrane transport

Disease: Atrial Fibrillation, Familial, 12; Cantu Syndrome; Cardiomyopathy, Dilated, 1o
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 Research Articles on ABCC9    1. single amino acid difference can account for the markedly different diazoxide sensitivities between channels containing either the SUR1 or SUR2A subunit isoforms.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ABCC9 cdna cloneDiseases associated with ABCC9 cdna clone
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ATP Sensitive Potassium Channels Pathway antibodies  ATP Sensitive Potassium Channels Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >12 publications with ABCC9 and Cardiovascular Diseases
 Heart Diseases Antibodies  >11 publications with ABCC9 and Heart Diseases
 Hypertrophy Antibodies  >4 publications with ABCC9 and Hypertrophy
 Arrhythmias, Cardiac Antibodies  >4 publications with ABCC9 and Arrhythmias, Cardiac
 Cantu syndrome Antibodies  >4 publications with ABCC9 and Cantu syndrome
 Fibrosis Antibodies  >2 publications with ABCC9 and Fibrosis
 Myocardial Infarction Antibodies  >2 publications with ABCC9 and Myocardial Infarction
 Death Antibodies  >1 publications with ABCC9 and Death
 Drug Toxicity Antibodies  >1 publications with ABCC9 and Drug Toxicity
 Neoplasms Antibodies  >1 publications with ABCC9 and Neoplasms
Organs/Tissues associated with ABCC9 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >17 publications with ABCC9 and Heart
 Muscle Antibodies  >11 publications with ABCC9 and Muscle
 Liver Antibodies  >5 publications with ABCC9 and Liver
 Brain Antibodies  >4 publications with ABCC9 and Brain
 Uterus Antibodies  >2 publications with ABCC9 and Uterus
 Testis Antibodies  >1 publications with ABCC9 and Testis
 Lung Antibodies  >1 publications with ABCC9 and Lung
 Kidney Antibodies  >1 publications with ABCC9 and Kidney
 Embryonic Tissue Antibodies  >1 publications with ABCC9 and Embryonic Tissue
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