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ABCE1 cdna clone

Scan QR to view Datasheet Catalog #    MBS1278091 ABCE1 cdna clone
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCE1, cDNA Clone

 Also Known As   

ABCE1 cDNA Clone

 Product Gene Name   

ABCE1 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    601213
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ABCE1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ABCE1. It may not necessarily be applicable to this product.
 NCBI GI #    16740841
 NCBI GeneID    6059
 NCBI Accession #    BC016283 [Other Products]
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 UniProt Secondary Accession #    O88793; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66 [Other Products]
 UniProt Related Accession #    P61221 [Other Products]
 Molecular Weight    67,314 Da
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 NCBI Official Full Name    Homo sapiens ATP-binding cassette, sub-family E (OABP), member 1, mRNA
 NCBI Official Synonym Full Names    ATP binding cassette subfamily E member 1
 NCBI Official Symbol    ABCE1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family E member 1
 UniProt Protein Name    ATP-binding cassette sub-family E member 1
 UniProt Synonym Protein Names   
2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I
 Protein Family    ABC transporter E family
 UniProt Gene Name    ABCE1 [Similar Products]
 UniProt Synonym Gene Names    RLI; RNASEL1; RNASELI; RNS4I; RNS4I [Similar Products]
 UniProt Entry Name    ABCE1_HUMAN
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 NCBI Summary for ABCE1    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCE1    ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family.

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: cytoplasm; eukaryotic translation initiation factor 3 complex; membrane; mitochondrial matrix; mitochondrion

Molecular Function: ATP binding; iron ion binding; protein binding; ribosomal small subunit binding

Biological Process: ribosome export from nucleus; translational initiation; translational termination; transmembrane transport
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 Research Articles on ABCE1    1. Downregulation of ABCE1 via siRNA affects the sensitivity of lung cancer cells against chemotherapeutic agents.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with ABCE1 cdna cloneOrgans/Tissues associated with ABCE1 cdna clone
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >13 publications with ABCE1 and Neoplasms
 Adenocarcinoma Antibodies  >4 publications with ABCE1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >4 publications with ABCE1 and Lung Neoplasms
 Liver Diseases Antibodies  >3 publications with ABCE1 and Liver Diseases
 Autoimmune Diseases Antibodies  >2 publications with ABCE1 and Autoimmune Diseases
 Intestinal Neoplasms Antibodies  >2 publications with ABCE1 and Intestinal Neoplasms
 Drug Toxicity Antibodies  >2 publications with ABCE1 and Drug Toxicity
 Liver Neoplasms Antibodies  >2 publications with ABCE1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with ABCE1 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >1 publications with ABCE1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with ABCE1 and Blood
 Lung Antibodies  >4 publications with ABCE1 and Lung
 Liver Antibodies  >3 publications with ABCE1 and Liver
 Prostate Antibodies  >2 publications with ABCE1 and Prostate
 Muscle Antibodies  >2 publications with ABCE1 and Muscle
 Skin Antibodies  >2 publications with ABCE1 and Skin
 Bone Marrow Antibodies  >1 publications with ABCE1 and Bone Marrow
 Pharynx Antibodies  >1 publications with ABCE1 and Pharynx
 Lymph Antibodies  >1 publications with ABCE1 and Lymph
 Intestine Antibodies  >1 publications with ABCE1 and Intestine
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