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| Product Name
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ABCE1, cDNA Clone
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| Also Known As
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ABCE1 cDNA Clone
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Molecular Biology Protocol
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| Frequently Asked Questions
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| Sequence
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atggcagaca agttaacgag aattgctatt gtcaaccatg acaaatgtaa acctaagaaa tgtcgacagg aatgcaaaaa gagttgtcct gtagttcgaa tgggaaaatt atgcatagag gttacacccc agagcaaaat agcatggatt tccgaaactc tttgtattgg ttgtggtatc tgtattaaga aatgcccctt tggcgcctta tcaattgtca atctaccaag caacttggaa aaagaaacca cacatcgata ttgtgccaat gccttcaaac ttcacaggtt gcctatccct cgtccaggtg aagttttggg attagttgga actaatggta ttggaaagtc aactgcttta aaaattttag caggaaaaca aaagccaaac cttggaaagt acgatgatcc tcctgactgg caggagattt tgacttattt ccgtggatct gaattacaaa attactttac aaagattcta gaagatgacc taaaagccat catcaaacct caatatgtag accagattcc taaggctgca aaggggacag tgggatctat tttggaccga aaagatgaaa caaagacaca ggcaattgta tgtcagcagc ttgatttaac ccacctaaaa gaacgaaatg ttgaagatct ttcaggagga gagttgcaga gatttgcttg tgctgtcgtt tgcatacaga aagctgatat tttcatgttt gatgagcctt ctagttacct agatgtcaag cagcgtttaa aggctgctat tactatacga tctctaataa atccagatag atatatcatt gtggtggaac atgatctaag tgtattagac tatctctccg acttcatctg ctgtttatat ggtgtaccaa gcgcctatgg agttgtcact atgcctttta gtgtaagaga aggcataaac atttttttgg atggctatgt tccaacagaa aacttgagat tcagagatgc atcacttgtt tttaaagtgg ctgagacagc aaatgaagaa gaagttaaaa agatgtgtat gtataaatat ccaggaatga agaaaaaaat gggagaattt gagctagcaa ttgtagctgg agagtttaca gattctgaaa ttatggtgat gctgggggaa aatggaacgg gtaaaacgac atttatcaga atgcttgctg gaagacttaa acctgatgaa ggaggagaag taccagttct aaatgtcagt tataagccac agaaaattag tcccaaatca actggaagtg ttcgccagtt actacatgaa aagataagag atgcttatac tcacccacaa tttgtgaccg atgtaatgaa gcctctgcaa attgaaaaca tcattgatca agaggtgcag acattatctg gtggtgaact acagcgagta gctttagccc tttgcttggg caaacctgct gatgtctatt taattgatga accatctgca tatttggatt ctgagcaaag actgatggca gctcgagttg tcaaacgttt catactccat gcaaaaaaga cagcctttgt tgtggaacat gacttcatca tggccaccta tctagcggat cgcgtcatcg tttttgatgg tgttccatct aagaacacag ttgcaaacag tcctcaaacc cttttggctg gcatgaataa atttttgtct cagcttgaaa ttacattcag aagagatcca aacaactata ggccacgaat aaacaaactt aattcaatta aggatgtaga acaaaagaag agtggaaact actttttctt ggatgattag
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| OMIM
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601213
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| Vector
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pENTR223.1 or pUC
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| Clone Sequence Report
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Provided with product shipment
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| ISO Certification
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Manufactured in an ISO 9001:2008 Certified Laboratory.
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| Other Notes
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Small volumes of ABCE1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| NCBI/Uniprot data below describe general gene information for ABCE1. It may not necessarily be applicable to this product. |
| NCBI GI #
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16740841
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| NCBI GeneID
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6059
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| NCBI Accession #
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BC016283
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[Other Products]
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| UniProt Secondary Accession #
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O88793; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66
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[Other Products]
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| UniProt Related Accession #
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P61221
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[Other Products]
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| Molecular Weight
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67,314 Da
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TOP
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| NCBI Official Full Name
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Homo sapiens ATP-binding cassette, sub-family E (OABP), member 1, mRNA
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| NCBI Official Synonym Full Names
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ATP binding cassette subfamily E member 1
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| NCBI Official Symbol
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ABCE1
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[Similar Products]
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| NCBI Official Synonym Symbols
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RLI; OABP; RLI1; ABC38; RNS4I; RNASEL1; RNASELI
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[Similar Products]
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| NCBI Protein Information
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ATP-binding cassette sub-family E member 1
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| UniProt Protein Name
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ATP-binding cassette sub-family E member 1
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| UniProt Synonym Protein Names
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2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I
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| Protein Family
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ABC transporter E family
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| UniProt Gene Name
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ABCE1
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[Similar Products]
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| UniProt Synonym Gene Names
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RLI; RNASEL1; RNASELI; RNS4I; RNS4I
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[Similar Products]
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| UniProt Entry Name
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ABCE1_HUMAN
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| NCBI Summary for ABCE1
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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| UniProt Comments for ABCE1
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ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family.
Chromosomal Location of Human Ortholog: 4q31
Cellular Component: cytoplasm; eukaryotic translation initiation factor 3 complex; membrane; mitochondrial matrix; mitochondrion
Molecular Function: ATP binding; iron ion binding; protein binding; ribosomal small subunit binding
Biological Process: ribosome export from nucleus; translational initiation; translational termination; transmembrane transport
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TOP
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| Research Articles on ABCE1
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1. Downregulation of ABCE1 via siRNA affects the sensitivity of lung cancer cells against chemotherapeutic agents.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Diseases associated with ABCE1 cdna clone | Organs/Tissues associated with ABCE1 cdna clone |
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TOP
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cDNA Clone 
