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ABCG8 cdna clone

Scan QR to view Datasheet Catalog #    MBS1274421 ABCG8 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCG8, cDNA Clone

★Popular Item★
 Also Known As   

ABCG8 cDNA Clone

 Product Gene Name   

ABCG8 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggccggga aggcggcaga ggagagaggg ctgccgaaag gggccactcc ccagcatacc tcgggcctcc aggatagatt gttctcctct gaaagtgaca acagcctgta cttcacctac agtggccagc ccaacaccct ggaggtcaga gacctcaact accaggtgga cctggcctct caggtccctt ggtttgagca gctggctcag ttcaagatgc cctggacatc tcccagctgc cagaattctt gtgagctggg catccagaac ctaagcttca aagtgagaag tgggcagatg ctggccatca tagggagctc aggttgtggg agagcctcct tgctagatgt gatcactggc cgaggtcacg gcggcaagat caagtcaggc cagatctgga tcaatgggca gcccagctcg cctcagctgg tgaggaagtg tgtggcccac gtgcgccagc acaaccagct gctccccaac ttgactgtgc gagagacctt ggccttcatt gcccagatgc ggctgcccag aaccttctcc caggcccagc gtgacaaaag ggtggaggac gtgatcgcgg agctgcggct taggcagtgc gctgacaccc gcgtgggcaa catgtacgtg cgggggttgt cggggggtga gcgcaggaga gtcagcattg gggtgcagct cctgtggaac ccaggaatcc ttattctcga cgaacccacc tctgggctcg acagcttcac agcccacaac ctggtgaaga ccttgtccag gctggccaaa ggcaaccggc tggtgctcat ctccctccac cagcctcgct ctgacatctt caggctgttt gatctggtcc tcctgatgac gtctggcacc cccatctact taggggcggc ccagcacatg gtccagtatt tcacagccat cggctacccc tgtcctcgct acagcaatcc tgctgacttc tatgtggacc tgaccagcat tgacaggcgc agcagagagc aggaattggc caccagggag aaggctcagt cactcgcagc cctgtttcta gaaaaagtgc gtgacttaga tgactttcta tggaaagcag agacgaagga tcttgacgag gacacctgtg tggaaagcag cgtgacccca ctagacacca actgcctccc gagtcctacg aagatgcctg gggcggtgca gcagtttacg acgctgatcc gtcgtcagat ttccaacgac ttccgagacc tgcccaccct cctcatccat ggggcggagg cctgtctgat gtcaatgacc atcggcttcc tctattttgg ccatgggagc atccagctct ccttcatgga tacagccgcc ctcttgttca tgatcggtgc tctcatccct ttcaacgtca ttctggatgt catctccaaa tgttactcag agagggcaat gctttactat gaactggaag acgggctgta caccactggt ccatatttct ttgccaagat cctcggggag cttccggagc actgtgccta catcatcatc tacgggatgc ccacctactg gctggccaac ctgaggccag gcctccagcc cttcctgctg cacttcctgc tggtgtggct ggtggtcttc tgttgcagga ttatggccct ggccgccgcg gccctgctcc ccaccttcca catggcctcc ttcttcagca atgccctcta caactccttc tacctcgccg ggggcttcat gataaacttg agcagcctgt ggacagtgcc cgcgtggatt tccaaagtgt ccttcctgcg gtggtgtttt gaagggctga tgaagattca gttcagcaga agaacttata aaatgcctct cgggaacctc accatcgcgg tctcaggaga taaaatcctc agtgccatgg agctggactc gtaccctctc tacgccatct acctcatcgt cattggcctc agcggtggct tcatggtcct gtactacgtg tccttaaggt tcatcaaaca gaaaccaagt caagactggt ga
 OMIM    210250
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ABCG8 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ABCG8. It may not necessarily be applicable to this product.
 NCBI GI #    109731354
 NCBI GeneID    64241
 NCBI Accession #    BC113657 [Other Products]
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 UniProt Secondary Accession #    Q53QN8 [Other Products]
 UniProt Related Accession #    Q9H221 [Other Products]
 Molecular Weight    75,592 Da
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 NCBI Official Full Name    Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 8, mRNA
 NCBI Official Synonym Full Names    ATP binding cassette subfamily G member 8
 NCBI Official Symbol    ABCG8 [Similar Products]
 NCBI Official Synonym Symbols   
GBD4; STSL
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family G member 8
 UniProt Protein Name    ATP-binding cassette sub-family G member 8
 UniProt Synonym Protein Names   
Sterolin-2
 Protein Family    ABC transporter G family
 UniProt Gene Name    ABCG8 [Similar Products]
 UniProt Entry Name    ABCG8_HUMAN
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 NCBI Summary for ABCG8    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions to exclude non-cholesterol sterol entry at the intestinal level, promote excretion of cholesterol and sterols into bile, and to facilitate transport of sterols back into the intestinal lumen. It is expressed in a tissue-specific manner in the liver, intestine, and gallbladder. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG5. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCG8    ABCG8: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Genetic variations in ABCG8 can be associated with susceptibility to gallbladder disease type 4 (GBD4). With an overall prevalence of 10-20%, gallstone disease (cholelithiasis) represents one of the most frequent and economically relevant health problems of industrialized countries. Defects in ABCG8 are a cause of sitosterolemia (STSL); also known as phytosterolemia or shellfish sterolemia. It is a rare autosomal recessive disorder characterized by increased intestinal absorption of all sterols including cholesterol, plant and shellfish sterols, and decreased biliary excretion of dietary sterols into bile. Sitosterolemia patients have hypercholesterolemia, very high levels of plant sterols in the plasma, and frequently develop tendon and tuberous xanthomas, accelerated atherosclerosis and premature coronary artery disease. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, ABC family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: apical plasma membrane; ATP-binding cassette (ABC) transporter complex; plasma membrane; receptor complex

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; cholesterol transporter activity; protein binding; protein heterodimerization activity

Biological Process: cholesterol absorption; cholesterol efflux; cholesterol homeostasis; excretion; negative regulation of cholesterol absorption; sterol transport; transmembrane transport

Disease: Gallbladder Disease 4; Sitosterolemia
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 Research Articles on ABCG8    1. Genetic polymorphism within the ABCG8 gene is a risk factor for diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ABCG8 cdna cloneDiseases associated with ABCG8 cdna clone
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ABCA Transporters In Lipid Homeostasis Pathway antibodies  ABCA Transporters In Lipid Homeostasis Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Sitosterolemia Antibodies  >65 publications with ABCG8 and Sitosterolemia
 Dyslipidemias Antibodies  >62 publications with ABCG8 and Dyslipidemias
 Atherosclerosis Antibodies  >56 publications with ABCG8 and Atherosclerosis
 Liver Diseases Antibodies  >43 publications with ABCG8 and Liver Diseases
 Gallstones Antibodies  >34 publications with ABCG8 and Gallstones
 Arteriosclerosis Antibodies  >29 publications with ABCG8 and Arteriosclerosis
 Fatty Liver Antibodies  >28 publications with ABCG8 and Fatty Liver
 Coronary Artery Disease Antibodies  >22 publications with ABCG8 and Coronary Artery Disease
 Heart Diseases Antibodies  >18 publications with ABCG8 and Heart Diseases
 Inflammation Antibodies  >16 publications with ABCG8 and Inflammation
Organs/Tissues associated with ABCG8 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with ABCG8 and Muscle
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