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ABHD5 cdna clone

Scan QR to view Datasheet Catalog #    MBS1270838 ABHD5 cdna clone
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABHD5, cDNA Clone

 Also Known As   

ABHD5 cDNA Clone

 Product Gene Name   

ABHD5 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    275630
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ABHD5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ABHD5. It may not necessarily be applicable to this product.
 NCBI GI #    18314390
 NCBI GeneID    51099
 NCBI Accession #    BC021958 [Other Products]
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 UniProt Secondary Accession #    Q9Y369; B2R9K0 [Other Products]
 UniProt Related Accession #    Q8WTS1 [Other Products]
 Molecular Weight    39,096 Da
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 NCBI Official Full Name    Homo sapiens abhydrolase domain containing 5, mRNA
 NCBI Official Synonym Full Names    abhydrolase domain containing 5
 NCBI Official Symbol    ABHD5 [Similar Products]
 NCBI Official Synonym Symbols   
CDS; CGI58; IECN2; NCIE2
[Similar Products]
 NCBI Protein Information    1-acylglycerol-3-phosphate O-acyltransferase ABHD5
 UniProt Protein Name    1-acylglycerol-3-phosphate O-acyltransferase ABHD5
 UniProt Synonym Protein Names   
Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58
 Protein Family    1-acylglycerol-3-phosphate O-acyltransferase
 UniProt Gene Name    ABHD5 [Similar Products]
 UniProt Synonym Gene Names    NCIE2 [Similar Products]
 UniProt Entry Name    ABHD5_HUMAN
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 NCBI Summary for ABHD5    The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABHD5    ABHD5: a lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Colocalized with PLIN and ADFP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues, and Chanarin-Dorfman syndrome (CDS), a triglyceride storage disease with impaired long-chain fatty acid oxidation and icthyosis. CDS is an autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons.

Protein type: Transferase; Lipase; EC 2.3.1.51

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lipid particle; nucleus

Molecular Function: lysophosphatidic acid acyltransferase activity; triacylglycerol lipase activity

Biological Process: phosphatidic acid biosynthetic process

Disease: Chanarin-dorfman Syndrome
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 Research Articles on ABHD5    1. Authors show that rat ATGL, coactivated by rat CGI-58, efficiently hydrolyzes triglycerides and retinyl ester.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ABHD5 cdna cloneDiseases associated with ABHD5 cdna clone
 Products by Pathway  Pathway Diagram
 CDP-diacylglycerol Biosynthesis I Pathway antibodies  CDP-diacylglycerol Biosynthesis I Pathway Diagram
 Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway antibodies  Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Phosphatidylglycerol Biosynthesis II (non-plastidic) Pathway antibodies  Phosphatidylglycerol Biosynthesis II (non-plastidic) Pathway Diagram
 Triacylglycerol Biosynthesis Pathway antibodies  Triacylglycerol Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >18 publications with ABHD5 and Liver Diseases
 Fatty Liver Antibodies  >15 publications with ABHD5 and Fatty Liver
 Muscular Diseases Antibodies  >11 publications with ABHD5 and Muscular Diseases
 Hepatomegaly Antibodies  >6 publications with ABHD5 and Hepatomegaly
 Triglyceride storage disease with impaired long-chain fatty acid oxidation Antibodies  >6 publications with ABHD5 and Triglyceride storage disease with impaired long-chain fatty acid oxidation
 Neoplasms Antibodies  >4 publications with ABHD5 and Neoplasms
 Liver Neoplasms Antibodies  >3 publications with ABHD5 and Liver Neoplasms
 Hypertrophy Antibodies  >3 publications with ABHD5 and Hypertrophy
 Cardiovascular Diseases Antibodies  >3 publications with ABHD5 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with ABHD5 and Carcinoma, Hepatocellular
Organs/Tissues associated with ABHD5 cdna clone
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >24 publications with ABHD5 and Liver
 Connective Tissue Antibodies  >19 publications with ABHD5 and Connective Tissue
 Skin Antibodies  >18 publications with ABHD5 and Skin
 Muscle Antibodies  >13 publications with ABHD5 and Muscle
 Blood Antibodies  >12 publications with ABHD5 and Blood
 Heart Antibodies  >4 publications with ABHD5 and Heart
 Kidney Antibodies  >1 publications with ABHD5 and Kidney
 Bone Marrow Antibodies  >1 publications with ABHD5 and Bone Marrow
 Eye Antibodies  >1 publications with ABHD5 and Eye
 Intestine Antibodies  >1 publications with ABHD5 and Intestine
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