BC002448
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
84,559 Da
NCBI Official Full Name
Homo sapiens actin binding LIM protein 1, mRNA
NCBI Official Synonym Full Names
actin binding LIM protein 1
NCBI Official Synonym Symbols
ABLIM; LIMAB1; LIMATIN; abLIM-1 [Similar Products]
NCBI Protein Information
actin-binding LIM protein 1
UniProt Protein Name
Actin-binding LIM protein 1
UniProt Synonym Protein Names
Actin-binding LIM protein family member 1; Actin-binding double zinc finger protein; LIMAB1; Limatin
UniProt Synonym Gene Names
UniProt Entry Name
ABLM1_HUMAN
NCBI Summary for ABLIM1
This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ABLIM1
abLIM: a cytoskeletal LIM protein consisting of a C-terminal cytoskeletal domain fused to an N-terminal domain of four double zinc finger motifs. The C-terminal domain is 50% identical to dematin, an actin-bundling protein of the erythroid cytoskeleton. Undergoes extensive phosphorylation in light-adapted retinas in vivo and its developmental expression in the retina coincides with the elaboration of photoreceptor inner and outer segments. Three distinct splice variant isoforms have been described: ABLIM-l, ABLIM-m, ABLIM-s.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Actin-binding
Chromosomal Location of Human Ortholog: 10q25
Cellular Component: actin cytoskeleton; lamellipodium; stress fiber
Molecular Function: protein binding
Biological Process: cilium biogenesis; lamellipodium biogenesis; organ morphogenesis; visual perception
Research Articles on ABLIM1
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Pathways associated with ABLIM1 cdna clone
Diseases associated with ABLIM1 cdna clone
Organs/Tissues associated with ABLIM1 cdna clone
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