BC066313
[Other Products]
UniProt Related Accession #
Molecular Weight
31,079 Da
NCBI Official Full Name
Homo sapiens activator of basal transcription 1, mRNA
NCBI Official Synonym Full Names
activator of basal transcription 1
NCBI Official Synonym Symbols
NCBI Protein Information
activator of basal transcription 1
UniProt Protein Name
Activator of basal transcription 1
UniProt Synonym Protein Names
Basal transcriptional activator
UniProt Synonym Gene Names
UniProt Entry Name
ABT1_HUMAN
NCBI Summary for ABT1
Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]
UniProt Comments for ABT1
ABT1: Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes. Belongs to the ESF2/ABP1 family.
Protein type: Nucleolus; Transcription factor; RNA-binding
Chromosomal Location of Human Ortholog: 6p22.2
Cellular Component: nucleolus; nucleus
Molecular Function: protein binding; RNA binding; transcription coactivator activity
Biological Process: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
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Diseases associated with ABT1 cdna clone
Organs/Tissues associated with ABT1 cdna clone
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