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ACSL4 cdna clone

Scan QR to view Datasheet Catalog #    MBS1270741 ACSL4 cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACSL4, cDNA Clone

★Popular Item★
 Also Known As   

ACSL4 cDNA Clone

 Product Gene Name   

ACSL4 cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggcaaaga gaataaaagc taagcccact tcagacaaac ctggaagtcc atatcgctct gtcacacact tcgactcact agctgtaata gacatccctg gagcagatac tctggataaa ttatttgacc atgctgtatc caagtttggg aagaaggaca gccttgggac cagggaaatc ctaagtgaag aaaatgaaat gcagccaaat ggaaaagttt ttaagaagtt aattcttggg aattataaat ggatgaacta tcttgaagtg aatcgcagag tgaataactt tggtagtgga ctcactgcac tgggactaaa accaaagaac accattgcca tcttctgtga gaccagggcc gaatggatga ttgcagcaca gacctgcttt aagtacaact ttcctcttgt gactttatat gccacacttg gcaaagaagc agtagttcat gggctaaatg aatctgaggc ttcctatctg attaccagtg ttgaacttct ggaaagtaaa cttaagactg cattgttaga tatcagttgt gttaaacata tcatttatgt ggacaataag gctatcaata aagcagagta ccctgaagga tttgagattc acagcatgca atcagtagaa gagttgggat ctaacccaga aaacttgggc attcctccaa gtagaccaac gccttcagac atggccattg ttatgtatac tagtggttct actggccgac ctaagggagt gatgatgcat catagcaatt tgatagctgg aatgacaggc cagtgtgaaa gaatacctgg actgggaccg aaggacacat atattggcta cttgcctttg gctcatgtgc tagaactgac agcagagata tcttgcttta cctatggctg caggattgga tattcttctc cgcttacact ctctgaccag tccagcaaaa ttaaaaaagg aagcaaagga gactgtactg tactgaagcc cacacttatg gctgctgttc cggaaatcat ggatagaatt tataagaatg ttatgagcaa agtccaagag atgaattata ttcagaaaac tctgttcaag atagggtatg attacaaatt ggaacagatc aaaaagggat atgatgcacc tctttgcaat ctgttactgt ttaaaaaggt caaggccctg ctgggaggga atgtccgcat gatgctgtct ggaggggccc cgctatctcc tcagacacac cgattcatga atgtctgctt ctgctgccca attggccagg gttatggact gacagaatca tgtggtgctg ggacagttac tgaagtaact gactatacta ctggcagagt tggagcacct cttatttgct gtgaaattaa gctaaaagac tggcaagaag gcggttatac aattaatgac aagccaaacc ccagaggtga aatcgtaatt ggtggacaga acatctccat gggatatttt aaaaatgaag agaaaacagc agaagattat tctgtggatg aaaatggaca aaggtggttt tgcactggtg atattggaga attccatccc gatggatgtt tacagattat agatcgtaag aaagatctag tgaagttaca agcaggagag tatgtatctc ttgggaaagt ggaagctgca ctgaagaatt gtccacttat tgacaacatc tgtgcttttg ccaaaagtga tcagtcctat gtgatcagtt ttgtggttcc taaccagaaa aggttgacac ttttggcaca acagaaaggg gtagaaggaa cttgggttga tatctgcaat aatcctgcta tggaagctga aatactgaaa gaaattcgag aagctgcaaa tgccatgaaa ttggagcgat ttgaaattcc aatcaaggtt cgattaagcc cagagccatg gacccctgaa actggtttgg taactgatgc tttcaaactg aaaaggaagg agctgaggaa ccattacctc aaagacattg aacgaatgta tgggggcaaa taa
 OMIM    300157
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ACSL4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ACSL4. It may not necessarily be applicable to this product.
 NCBI GI #    34194222
 NCBI GeneID    2182
 NCBI Accession #    BC034959 [Other Products]
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 UniProt Secondary Accession #    O60848; O60849; Q5JWV8; D3DUY2 [Other Products]
 UniProt Related Accession #    O60488 [Other Products]
 Molecular Weight    74,436 Da
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 NCBI Official Full Name    Homo sapiens acyl-CoA synthetase long-chain family member 4, mRNA
 NCBI Official Synonym Full Names    acyl-CoA synthetase long-chain family member 4
 NCBI Official Symbol    ACSL4 [Similar Products]
 NCBI Official Synonym Symbols   
ACS4; FACL4; LACS4; MRX63; MRX68
[Similar Products]
 NCBI Protein Information    long-chain-fatty-acid--CoA ligase 4
 UniProt Protein Name    Long-chain-fatty-acid--CoA ligase 4
 UniProt Synonym Protein Names   
Long-chain acyl-CoA synthetase 4; LACS 4
 UniProt Gene Name    ACSL4 [Similar Products]
 UniProt Synonym Gene Names    ACS4; FACL4; LACS4; LACS 4 [Similar Products]
 UniProt Entry Name    ACSL4_HUMAN
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 NCBI Summary for ACSL4    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]
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 UniProt Comments for ACSL4    ACSL4: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. Defects in ACSL4 are the cause of mental retardation X- linked type 63 (MRX63). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Defects in ACSL4 are involved in Alport syndrome with mental retardation midface hypoplasia and elliptocytosis (ATS-MR). A X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, deafness, mental retardation, midface hypoplasia and elliptocytosis. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - fatty acid; Membrane protein, integral; Ligase; EC 6.2.1.3

Chromosomal Location of Human Ortholog: Xq22.3-q23

Cellular Component: cytoplasm; endoplasmic reticulum membrane; lipid particle; membrane

Molecular Function: arachidonate-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity; very-long-chain-fatty-acid-CoA ligase activity

Biological Process: lipid metabolic process

Disease: Mental Retardation, X-linked 63
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 Research Articles on ACSL4    1. In vitro analysis showed that a recombinant COX-2 enzyme more effectively metabolized 5(S)-HETE to 5-11-diHETE compared to COX-1 enzyme.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ACSL4 cdna cloneDiseases associated with ACSL4 cdna clone
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >9 publications with ACSL4 and Fatty Liver
 Nervous System Diseases Antibodies  >7 publications with ACSL4 and Nervous System Diseases
 Neoplasms Antibodies  >3 publications with ACSL4 and Neoplasms
 Liver Diseases Antibodies  >3 publications with ACSL4 and Liver Diseases
 Abnormalities, Multiple Antibodies  >2 publications with ACSL4 and Abnormalities, Multiple
 Carcinoma, Hepatocellular Antibodies  >2 publications with ACSL4 and Carcinoma, Hepatocellular
 Atherosclerosis Antibodies  >1 publications with ACSL4 and Atherosclerosis
 Brain Diseases Antibodies  >1 publications with ACSL4 and Brain Diseases
 Kidney Diseases Antibodies  >1 publications with ACSL4 and Kidney Diseases
 Inflammation Antibodies  >1 publications with ACSL4 and Inflammation
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