BC012172
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,087 Da
NCBI Official Full Name
Homo sapiens acyl-CoA synthetase short-chain family member 2, mRNA
NCBI Official Synonym Full Names
acyl-CoA synthetase short-chain family member 2
NCBI Official Synonym Symbols
ACS; ACSA; ACAS2; ACECS; dJ1161H23.1 [Similar Products]
NCBI Protein Information
acetyl-coenzyme A synthetase, cytoplasmic
UniProt Protein Name
Acetyl-coenzyme A synthetase, cytoplasmic
UniProt Synonym Protein Names
Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme
UniProt Synonym Gene Names
UniProt Entry Name
ACSA_HUMAN
NCBI Summary for ACSS2
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
UniProt Comments for ACSS2
ACSS2: Activates acetate so that it can be used for lipid synthesis or for energy generation. Monomer. Belongs to the ATP-dependent AMP-binding enzyme family.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; nucleoplasm
Molecular Function: acetate-CoA ligase activity; AMP binding
Biological Process: ethanol oxidation; lipid biosynthetic process
Research Articles on ACSS2
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Pathways associated with ACSS2 cdna clone
Diseases associated with ACSS2 cdna clone
Organs/Tissues associated with ACSS2 cdna clone
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