BC030812
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
90,065 Da
NCBI Official Full Name
Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 4, mRNA
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 4
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 4
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 4
UniProt Synonym Protein Names
ADMP-1; Aggrecanase-1
UniProt Synonym Gene Names
UniProt Entry Name
ATS4_HUMAN
NCBI Summary for ADAMTS4
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
UniProt Comments for ADAMTS4
ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Protein type: Secreted; Protease; Secreted, signal peptide; Motility/polarity/chemotaxis; EC 3.4.24.82
Chromosomal Location of Human Ortholog: 1q21-q23
Cellular Component: extracellular matrix; extracellular region; extracellular space
Molecular Function: metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protease binding; protein binding
Biological Process: extracellular matrix disassembly; skeletal development
Research Articles on ADAMTS4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with ADAMTS4 cdna clone
Diseases associated with ADAMTS4 cdna clone
Organs/Tissues associated with ADAMTS4 cdna clone
|