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ADC cdna clone

Scan QR to view Datasheet Catalog #    MBS1273448 ADC cdna clone
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADC, cDNA Clone

 Also Known As   

ADC cDNA Clone

 Product Gene Name   

ADC cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    Please Inquire
 OMIM    608353
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 Vector    Please Inquire
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ADC cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ADC. It may not necessarily be applicable to this product.
 NCBI GI #    14714622
 NCBI GeneID    113451
 NCBI Accession #    BC010449 [Other Products]
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 UniProt Secondary Accession #    Q5TIF4; Q5TIF5; Q5TIF6; Q8TF56; Q96L54; Q96L55; Q96L56; Q96L57; Q96MD9; B2RDU5; D3DPQ9 [Other Products]
 UniProt Related Accession #    Q96A70 [Other Products]
 Molecular Weight    22,300 Da
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 NCBI Official Full Name    Homo sapiens arginine decarboxylase, mRNA
 NCBI Official Synonym Full Names    antizyme inhibitor 2
 NCBI Official Symbol    AZIN2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    antizyme inhibitor 2
 UniProt Protein Name    Antizyme inhibitor 2
 UniProt Synonym Protein Names   
Arginine decarboxylase; ADC; ARGDC; Ornithine decarboxylase-like protein; ODC-like protein; ornithine decarboxylase paralog; ODC-p
 Protein Family    Acetoacetate decarboxylase
 UniProt Gene Name    AZIN2 [Similar Products]
 UniProt Synonym Gene Names    ADC; KIAA1945; ODCP; AzI2; ADC; ARGDC; ODC-like protein; ODC-p [Similar Products]
 UniProt Entry Name    AZIN2_HUMAN
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 NCBI Summary for ADC    The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
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 UniProt Comments for ADC    ADC: Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity. Belongs to the Orn/Lys/Arg decarboxylase class-II family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; EC; Amino Acid Metabolism - arginine and proline; Lyase

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: axon; cis-Golgi network; cytoplasmic vesicle; cytosol; dendrite; ER-Golgi intermediate compartment membrane; nucleus; perikaryon; perinuclear region of cytoplasm; trans-Golgi network; transport vesicle

Molecular Function: arginine decarboxylase activity; ornithine decarboxylase activator activity; protein binding; putrescine transmembrane transporter activity

Biological Process: negative regulation of protein catabolic process; positive regulation of catalytic activity; putrescine biosynthetic process from ornithine; putrescine transport
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 Research Articles on ADC    1. ODC activity is mostly linked to cell proliferation, whereas its regulation by AZIN2 in post-mitotically differentiated neurons of the brain apparently serves different purposes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ADC cdna cloneDiseases associated with ADC cdna clone
 Products by Pathway  Pathway Diagram
 Agmatine Biosynthesis Pathway antibodies  Agmatine Biosynthesis Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Polyamines Pathway antibodies  Metabolism Of Polyamines Pathway Diagram
 Polyamine Biosynthesis, Arginine => Agmatine => Putrescine => Spermidine Pathway antibodies  Polyamine Biosynthesis, Arginine => Agmatine => Putrescine => Spermidine Pathway Diagram
 Polyamine Biosynthesis, Arginine => Agmatine => Putrescine => Spermidine Pathway antibodies  Polyamine Biosynthesis, Arginine => Agmatine => Putrescine => Spermidine Pathway Diagram
 Putrescine Biosynthesis III Pathway antibodies  Putrescine Biosynthesis III Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >3232 publications with ADC and Brain Diseases
 Neoplasms Antibodies  >2633 publications with ADC and Neoplasms
 Kidney Diseases Antibodies  >817 publications with ADC and Kidney Diseases
 Bone Diseases Antibodies  >755 publications with ADC and Bone Diseases
 Liver Diseases Antibodies  >673 publications with ADC and Liver Diseases
 Inflammation Antibodies  >427 publications with ADC and Inflammation
 Seizures Antibodies  >366 publications with ADC and Seizures
 Necrosis Antibodies  >340 publications with ADC and Necrosis
 Genital Diseases, Male Antibodies  >293 publications with ADC and Genital Diseases, Male
 Disease Models, Animal Antibodies  >267 publications with ADC and Disease Models, Animal
Organs/Tissues associated with ADC cdna clone
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2716 publications with ADC and Brain
 Lung Antibodies  >1037 publications with ADC and Lung
 Heart Antibodies  >771 publications with ADC and Heart
 Skin Antibodies  >749 publications with ADC and Skin
 Kidney Antibodies  >722 publications with ADC and Kidney
 Intestine Antibodies  >489 publications with ADC and Intestine
 Connective Tissue Antibodies  >219 publications with ADC and Connective Tissue
 Thyroid Antibodies  >189 publications with ADC and Thyroid
 Eye Antibodies  >183 publications with ADC and Eye
 Stomach Antibodies  >147 publications with ADC and Stomach
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