BC020988
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,496 Da
NCBI Official Full Name
Homo sapiens apoptosis enhancing nuclease, mRNA
NCBI Official Synonym Full Names
apoptosis enhancing nuclease
NCBI Protein Information
apoptosis-enhancing nuclease
UniProt Protein Name
Apoptosis-enhancing nuclease
UniProt Synonym Protein Names
Interferon-stimulated 20 kDa exonuclease-like 1
UniProt Synonym Gene Names
UniProt Entry Name
AEN_HUMAN
UniProt Comments for AEN
AEN: Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.-.-; Nucleolus; Hydrolase; Apoptosis
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: nuclear membrane; nucleolus; nucleoplasm; nucleus
Molecular Function: exonuclease activity; protein binding
Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to ionizing radiation
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Diseases associated with AEN cdna clone
Organs/Tissues associated with AEN cdna clone
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