BC025700
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,823 Da
NCBI Official Full Name
Homo sapiens AF4/FMR2 family, member 4, mRNA
NCBI Official Synonym Full Names
AF4/FMR2 family member 4
NCBI Protein Information
AF4/FMR2 family member 4
UniProt Protein Name
AF4/FMR2 family member 4
UniProt Synonym Protein Names
ALL1-fused gene from chromosome 5q31 protein; Protein AF-5q31; Major CDK9 elongation factor-associated protein
UniProt Synonym Gene Names
UniProt Entry Name
AFF4_HUMAN
NCBI Summary for AFF4
The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
UniProt Comments for AFF4
MCEF: a putative transcription factor. Component of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor b (P-TEFb). Genetic fusion of its gene with MLL has been observed in a subset of acute lymphoblastic leukemia patients. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Oncoprotein
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: transcription elongation factor complex
Molecular Function: protein binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter
Disease: Chops Syndrome
Research Articles on AFF4
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Diseases associated with AFF4 cdna clone
Organs/Tissues associated with AFF4 cdna clone
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