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AGT cdna clone

Scan QR to view Datasheet Catalog #    MBS1270701 AGT cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AGT, cDNA Clone

★Popular Item★
 Also Known As   

AGT cDNA Clone

 Product Gene Name   

AGT cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atgcggaagc gagcacccca gtctgagatg gctcctgccg gtgtgagcct gagggccacc atcctctgcc tcctggcctg ggctggcctg gctgcaggtg accgggtgta catacacccc ttccacctcg tcatccacaa tgagagtacc tgtgagcagc tggcaaaggc caatgccggg aagcccaaag accccacctt catacctgct ccaattcagg ccaagacatc ccctgtggat gaaaaggccc tacaggacca gctggtgcta gtcgctgcaa aacttgacac cgaagacaag ttgagggccg caatggtcgg gatgctggcc aacttcttgg gcttccgtat atatggcatg cacagtgagc tatggggcgt ggtccatggg gccaccgtcc tctccccaac ggctgtcttt ggcaccctgg cctctctcta tctgggagcc ttggaccaca cagctgacag gctacaggca atcctgggtg ttccttggaa ggacaagaac tgcacctccc ggctggatgc gcacaaggtc ctgtctgccc tgcaggctgt acagggcctg ctagtggccc agggcagggc tgatagccag gcccagctgc tgctgtccac ggtggtgggc gtgttcacag ccccaggcct gcacctgaag cagccgtttg tgcagggcct ggctctctat acccctgtgg tcctcccacg ctctctggac ttcacagaac tggatgttgc tgctgagaag attgacaggt tcatgcaggc tgtgacagga tggaagactg gctgctccct gacgggagcc agtgtggaca gcaccctggc tttcaacacc tacgtccact tccaagggaa gatgaagggc ttctccctgc tggccgagcc ccaggagttc tgggtggaca acagcacctc agtgtctgtt cccatgctct ctggcatggg caccttccag cactggagtg acatccagga caacttctcg gtgactcaag tgtccttcac tgagagcgcc tgcctgctgc tgatccagcc tcactatgcc tctgacctgg acaaggtgga gggtctcact ttccagcaaa actccctcaa ctggatgaag aaactgtctc cccggaccat ccacctgacc atgccccaac tggtgctgca aggatcttat gacctgcagg acctgctcgc ccaggctgag ctgcccgcca ttctgcacac cgagctgaac ctgcaaaaat tgagcaatga ccgcatcagg gtgggggagg tgctgaacag catttttttt gagcttgaag cggatgagag agagcccaca gagtctaccc aacagcttaa caagcctgag gtcttggagg tgaccctgaa ccgcccattc ctgtttgctg tgtatgatca aagcgccact gccctgcact tcctgggccg cgtggccaac ccgctgagca cagcatga
 OMIM    106150
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 Vector    pENTR223.1
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AGT cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for AGT. It may not necessarily be applicable to this product.
 NCBI GI #    15079347
 NCBI GeneID    183
 NCBI Accession #    BC011519 [Other Products]
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 UniProt Secondary Accession #    Q16358; Q16359; Q96F91 [Other Products]
 UniProt Related Accession #    P01019 [Other Products]
 Molecular Weight    53,154 Da
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 NCBI Official Full Name    Homo sapiens angiotensinogen (serpin peptidase inhibitor, clade A, member 8), mRNA
 NCBI Official Synonym Full Names    angiotensinogen
 NCBI Official Symbol    AGT [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    angiotensinogen
 UniProt Protein Name    Angiotensinogen
 UniProt Synonym Protein Names   
Serpin A8
 Protein Family    Angiotensinogen
 UniProt Gene Name    AGT [Similar Products]
 UniProt Synonym Gene Names    SERPINA8; Ang I; Ang II; Ang III; Ang IV [Similar Products]
 UniProt Entry Name    ANGT_HUMAN
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 NCBI Summary for AGT    The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AGT    angiotensin: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1- 8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2. Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. Defects in AGT are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q42.2

Cellular Component: extracellular region; extracellular space

Molecular Function: growth factor activity; hormone activity; protein binding; serine-type endopeptidase inhibitor activity; type 1 angiotensin receptor binding; type 2 angiotensin receptor binding

Biological Process: activation of NF-kappaB transcription factor; angiotensin maturation; blood vessel remodeling; cell-cell signaling; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cGMP nucleotide second messenger; kidney development; negative regulation of nerve growth factor receptor signaling pathway; nitric oxide mediated signal transduction; positive regulation of cellular protein metabolic process; positive regulation of cytokine production; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of transcription, DNA-dependent; regulation of blood pressure; renal system process; renin-angiotensin regulation of blood vessel size; response to muscle activity involved in regulation of muscle adaptation

Disease: Hypertension, Essential; Renal Tubular Dysgenesis
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 Research Articles on AGT    1. The ACE2-Ang (1-7)-Mas axis serves as an important signal pathway in endothelial cell protection in diabetic human arteries.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with AGT cdna cloneDiseases associated with AGT cdna clone
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >538 publications with AGT and Cardiovascular Diseases
 Hypertension Antibodies  >508 publications with AGT and Hypertension
 Kidney Diseases Antibodies  >247 publications with AGT and Kidney Diseases
 Heart Diseases Antibodies  >163 publications with AGT and Heart Diseases
 Hypertension, Renal Antibodies  >114 publications with AGT and Hypertension, Renal
 Myocardial Ischemia Antibodies  >98 publications with AGT and Myocardial Ischemia
 Hypertrophy Antibodies  >73 publications with AGT and Hypertrophy
 Atherosclerosis Antibodies  >66 publications with AGT and Atherosclerosis
 Myocardial Infarction Antibodies  >59 publications with AGT and Myocardial Infarction
 Proteinuria Antibodies  >57 publications with AGT and Proteinuria
Organs/Tissues associated with AGT cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >662 publications with AGT and Blood
 Kidney Antibodies  >279 publications with AGT and Kidney
 Liver Antibodies  >275 publications with AGT and Liver
 Heart Antibodies  >148 publications with AGT and Heart
 Brain Antibodies  >116 publications with AGT and Brain
 Lung Antibodies  >70 publications with AGT and Lung
 Muscle Antibodies  >65 publications with AGT and Muscle
 Bone Antibodies  >61 publications with AGT and Bone
 Connective Tissue Antibodies  >50 publications with AGT and Connective Tissue
 Ovary Antibodies  >37 publications with AGT and Ovary
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