BC037567
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,857 Da
NCBI Official Full Name
Homo sapiens alanine-glyoxylate aminotransferase 2-like 2, mRNA
NCBI Official Synonym Full Names
5-phosphohydroxy-L-lysine phospho-lyase
NCBI Protein Information
5-phosphohydroxy-L-lysine phospho-lyase
UniProt Protein Name
5-phosphohydroxy-L-lysine phospho-lyase
UniProt Synonym Protein Names
Alanine--glyoxylate aminotransferase 2-like 2
UniProt Synonym Gene Names
UniProt Entry Name
AT2L2_HUMAN
NCBI Summary for AGXT2L2
This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Comments for AGXT2L2
AGXT2L2: Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transferase; EC 4.2.3.134
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: mitochondrial matrix
Molecular Function: identical protein binding; lyase activity; protein binding; pyridoxal phosphate binding
Biological Process: collagen catabolic process; lysine catabolic process
Disease: Phosphohydroxylysinuria
Research Articles on AGXT2L2
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Pathways associated with AGXT2L2 cdna clone
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