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AICDA cdna clone

Scan QR to view Datasheet Catalog #    MBS1269402 AICDA cdna clone
Unit / Price
0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AICDA, cDNA Clone

 Also Known As   

AICDA cDNA Clone

 Product Gene Name   

AICDA cdna clone

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Molecular Biology Protocol    Molecular Biology Protocol
 Frequently Asked Questions    Frequently Asked Questions
 Sequence    atggacagcc tcttgatgaa ccggaggaag tttctttacc aattcaaaaa tgtccgctgg gctaagggtc ggcgtgagac ctacctgtgc tacgtagtga agaggcgtga cagtgctaca tccttttcac tggactttgg ttatcttcgc aataagaacg gctgccacgt ggaattgctc ttcctccgct acatctcgga ctgggaccta gaccctggcc gctgctaccg cgtcacctgg ttcacctcct ggagcccctg ctacgactgt gcccgacatg tggccgactt tctgcgaggg aaccccaacc tcagtctgag gatcttcacc gcgcgcctct acttctgtga ggaccgcaag gctgagcccg aggggctgcg gcggctgcac cgcgccgggg tgcaaatagc catcatgacc ttcaaagatt atttttactg ctggaatact tttgtagaaa accatgaaag aactttcaaa gcctgggaag ggctgcatga aaattcagtt cgtctctcca gacagcttcg gcgcatcctt ttgcccctgt atgaggttga tgacttacga gacgcatttc gtactttggg actttga
 OMIM    605257
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 Vector    pENTR223.1 or pUC
 Clone Sequence Report    Provided with product shipment
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AICDA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for AICDA. It may not necessarily be applicable to this product.
 NCBI GI #    33871601
 NCBI GeneID    57379
 NCBI Accession #    BC006296 [Other Products]
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 UniProt Secondary Accession #    Q6QJ81; Q8NFC1 [Other Products]
 UniProt Related Accession #    Q9GZX7 [Other Products]
 Molecular Weight    22,614 Da
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 NCBI Official Full Name    Homo sapiens activation-induced cytidine deaminase, mRNA
 NCBI Official Synonym Full Names    activation induced cytidine deaminase
 NCBI Official Symbol    AICDA [Similar Products]
 NCBI Official Synonym Symbols   
AID; ARP2; CDA2; HIGM2; HEL-S-284
[Similar Products]
 NCBI Protein Information    single-stranded DNA cytosine deaminase
 UniProt Protein Name    Single-stranded DNA cytosine deaminase
 UniProt Synonym Protein Names   
Activation-induced cytidine deaminase; Cytidine aminohydrolase
 Protein Family    Single-stranded DNA cytosine deaminase
 UniProt Gene Name    AICDA [Similar Products]
 UniProt Synonym Gene Names    AID [Similar Products]
 UniProt Entry Name    AICDA_HUMAN
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 NCBI Summary for AICDA    This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
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 UniProt Comments for AICDA    AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: Hydrolase; EC 3.5.4.38

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasm; exosome (RNase complex); nucleus

Molecular Function: cytidine deaminase activity; protein binding; ubiquitin protein ligase binding

Biological Process: somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes

Disease: Immunodeficiency With Hyper-igm, Type 2
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 Research Articles on AICDA    1. AICDA/APOBEC family of cytidine deaminases is significant in innate immunity, as it restricts numerous viruses, including HBV, through hypermutationdependent and independent mechanisms. (Review)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with AICDA cdna cloneDiseases associated with AICDA cdna clone
 Products by Pathway  Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Pyrimidine Deoxyribonucleosides Degradation Pathway antibodies  Pyrimidine Deoxyribonucleosides Degradation Pathway Diagram
 Pyrimidine Deoxyribonucleosides Salvage Pathway antibodies  Pyrimidine Deoxyribonucleosides Salvage Pathway Diagram
 Pyrimidine Ribonucleosides Degradation Pathway antibodies  Pyrimidine Ribonucleosides Degradation Pathway Diagram
 Pyrimidine Ribonucleosides Salvage I Pathway antibodies  Pyrimidine Ribonucleosides Salvage I Pathway Diagram
 Superpathway Of Pyrimidine Deoxyribonucleoside Salvage antibodies  Superpathway Of Pyrimidine Deoxyribonucleoside Salvage Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >189 publications with AICDA and Neoplasms
 Leukemia, Lymphoid Antibodies  >40 publications with AICDA and Leukemia, Lymphoid
 Inflammation Antibodies  >29 publications with AICDA and Inflammation
 Autoimmune Diseases Antibodies  >29 publications with AICDA and Autoimmune Diseases
 IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 2 Antibodies  >18 publications with AICDA and IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 2
 Liver Diseases Antibodies  >15 publications with AICDA and Liver Diseases
 Adenocarcinoma Antibodies  >11 publications with AICDA and Adenocarcinoma
 Nervous System Diseases Antibodies  >7 publications with AICDA and Nervous System Diseases
 Hyperplasia Antibodies  >6 publications with AICDA and Hyperplasia
 Breast Neoplasms Antibodies  >6 publications with AICDA and Breast Neoplasms
Organs/Tissues associated with AICDA cdna clone
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >391 publications with AICDA and Blood
 Lymph Node Antibodies  >79 publications with AICDA and Lymph Node
 Kidney Antibodies  >25 publications with AICDA and Kidney
 Lymph Antibodies  >20 publications with AICDA and Lymph
 Tonsil Antibodies  >11 publications with AICDA and Tonsil
 Pharynx Antibodies  >7 publications with AICDA and Pharynx
 Testis Antibodies  >2 publications with AICDA and Testis
 Pancreas Antibodies  >1 publications with AICDA and Pancreas
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