BC006296
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,614 Da
NCBI Official Full Name
Homo sapiens activation-induced cytidine deaminase, mRNA
NCBI Official Synonym Full Names
activation induced cytidine deaminase
NCBI Official Synonym Symbols
AID; ARP2; CDA2; HIGM2; HEL-S-284 [Similar Products]
NCBI Protein Information
single-stranded DNA cytosine deaminase
UniProt Protein Name
Single-stranded DNA cytosine deaminase
UniProt Synonym Protein Names
Activation-induced cytidine deaminase; Cytidine aminohydrolase
UniProt Synonym Gene Names
UniProt Entry Name
AICDA_HUMAN
NCBI Summary for AICDA
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
UniProt Comments for AICDA
AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.
Protein type: Hydrolase; EC 3.5.4.38
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: cytoplasm; exosome (RNase complex); nucleus
Molecular Function: cytidine deaminase activity; protein binding; ubiquitin protein ligase binding
Biological Process: somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes
Disease: Immunodeficiency With Hyper-igm, Type 2
Research Articles on AICDA
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Pathways associated with AICDA cdna clone
Diseases associated with AICDA cdna clone
Organs/Tissues associated with AICDA cdna clone
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