BC030589
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,137 Da
NCBI Official Full Name
Homo sapiens aldehyde dehydrogenase 1 family, member A2, mRNA
NCBI Official Synonym Full Names
aldehyde dehydrogenase 1 family member A2
NCBI Protein Information
retinal dehydrogenase 2
UniProt Protein Name
Retinal dehydrogenase 2
UniProt Synonym Protein Names
Aldehyde dehydrogenase family 1 member A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II)
UniProt Synonym Gene Names
UniProt Entry Name
AL1A2_HUMAN
NCBI Summary for ALDH1A2
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]
UniProt Comments for ALDH1A2
ALDH1A2: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; EC 1.2.1.36
Chromosomal Location of Human Ortholog: 15q21.3
Cellular Component: cytoplasm; cytosol
Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; retinal binding; retinal dehydrogenase activity
Biological Process: negative regulation of cell proliferation; neural tube development; response to cytokine stimulus; retinoic acid metabolic process
Research Articles on ALDH1A2
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Pathways associated with ALDH1A2 cdna clone
Diseases associated with ALDH1A2 cdna clone
Organs/Tissues associated with ALDH1A2 cdna clone
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